A Sponge-Like Double-Layer Wound Dressing with Chitosan and Decellularized Bovine Amniotic Membrane for Promoting Diabetic Wound Healing

Polymers
Yang YangLiping Teng

Abstract

The diabetic wounds do not heal easily in part because they are susceptible to infection due to environmental influences. Wound dressing is crucial to wound healing, as it can basically protect the wound from external damages and provide a suitable microenvironment for tissue regeneration. In this study, a double-layer membrane that consists of chitosan sponge and decellularized bovine amniotic membrane (dBAM) has been developed by freeze-casting method. The results showed that the porous structure of the sponge layer improved the performances of blood coagulation and swelling. The dense dBAM can optimize the mechanical property of wound dressing. In vitro studies revealed that the bilayer membrane had favorable biocompatible, especially for human foreskin fibroblast cells (HFF-1) cell adhesion and proliferation. Moreover, the full-thickness skin defects of diabetic model mice that treated with bilayer membrane showed over 80% closure in 8 days. Our findings imply that the double-layer dressing has great potentials to be used in diabetic patients.

References

Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J R HiltonK G Harding
Jul 22, 2008·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Mushik ParkDaegu Son
Jan 26, 2011·Biotechnology Advances·R JayakumarH Tamura
Mar 26, 2011·Expert Review of Ophthalmology·Jingbo LiuScheffer Cg Tseng
Aug 4, 2011·Expert Review of Anti-infective Therapy·Tianhong DaiMichael R Hamblin
May 18, 2012·Cell and Tissue Research·A C MamedeM F Botelho
Nov 7, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jing ChangZhongwei Gu
Mar 21, 2013·Archives of Pharmacal Research·Mirin KangAe-Ri Cho Lee
Sep 26, 2013·International Journal of Biological Macromolecules·B S AnishaR Jayakumar
Mar 19, 2014·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Seonguk MinDae Hun Suh
Jan 15, 2016·British Medical Bulletin·Dusko IlicEmilija Lazic Ilic
Mar 17, 2016·Journal of the American Academy of Dermatology·Laurel M Morton, Tania J Phillips
Jun 18, 2016·Current Eye Research·Mona BischoffNóra Szentmáry
Feb 13, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Megan S LordArthur A DeCarlo
Apr 17, 2017·International Journal of Biological Macromolecules·Ijaz BanoMuhammad Younus
Feb 18, 2018·International Journal of Biological Macromolecules·Yu XieQiong Jiang
Apr 18, 2019·Nature Reviews. Immunology·Allen W Ho, Thomas S Kupper
Apr 29, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Huiyan YingJinghua Chen
May 16, 2019·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Viorica PatruleaOlivier Jordan
Jan 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Huan ChengXiaofeng Sui
Nov 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Arun Prabhu RameshbabuSantanu Dhara

❮ Previous
Next ❯

Citations

Feb 2, 2021·Frontiers in Bioengineering and Biotechnology·Fatemeh Dadkhah TehraniAzadeh Shabani
Aug 28, 2021·Micromachines·Shahrukh Zaman AkashShazid Md Sharker

❮ Previous
Next ❯

Methods Mentioned

BETA
scanning electron microscopy

Software Mentioned

Bruker OPUS
dBAM

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

British Journal of Industrial Medicine
J T SCALES
Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Y KuroyanagiN Shioya
Nursing RSA = Verpleging RSA
P M Mertz
[Kango gijutsu] : [Nursing technique]
N Aikawa
© 2021 Meta ULC. All rights reserved