PMID: 9659298Jul 11, 1998Paper

A spontaneous induction of fetal membrane prostaglandin production precedes clinical labour

The Journal of Endocrinology
N L BrownM H Sullivan

Abstract

Fetal membranes from term human pregnancies produce prostaglandins, and may respond to bacterial endotoxin or interleukin-1 beta (IL-1 beta) with increased prostaglandin E2 (PGE2) production. The effects of endotoxin persisted for up to 24 h, whereas those of IL-1 beta were maximal 4-8 h after addition. The maximum levels of PGE2 (200-350 pg/ml) were similar in all experiments, and were independent of the stimulus used. Not all tissues responded to these stimuli; those which did not had basal levels of PGE2 production of 200-350 pg/ml, which was not further increased by endotoxin or IL-1 beta. The basal production from these tissues was therefore similar to the maximal production from those tissues which responded to endotoxin or IL-1 beta. The high basal production of PGE2 was attributed to prior in vivo activation of the membranes such that PGE2 synthesis could not be further stimulated in vitro. Overnight pretreatment with aspirin decreased basal PGE2 production from these activated membranes to < 100 pg/ml/4 h during subsequent culture in aspirin-free medium. Both endotoxin and IL-1 beta increased PGE2 production from the activated aspirin-pretreated membranes during this culture time, but this was transient as after 12 h o...Continue Reading

Citations

Jun 24, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Robert J SawdyPhillip R Bennett
Nov 3, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·Tamsin M Lindström, Phillip R Bennett
Dec 20, 2015·Cytokine & Growth Factor Reviews·Mathieu Nadeau-ValléeSylvain Chemtob
Feb 3, 2011·American Journal of Obstetrics and Gynecology·Pooja MittalSonia S Hassan
Nov 24, 2005·Journal of the Society for Gynecologic Investigation·Hannah K PalliserI Ross Young
Nov 21, 2017·Reproductive Sciences·Kanchan VaswaniMurray D Mitchell
May 2, 2008·Obstetrics and Gynecology·Kristin SkogstrandPoul Thorsen
May 6, 2015·Journal of Perinatal Medicine·Roberto RomeroLami Yeo
Oct 21, 2000·Endocrine Reviews· Challis JRGS J Lye
Jun 18, 2020·Journal of Inflammation Research·Sedigheh HantoushzadehAmir Hossein Norooznezhad
Mar 17, 2009·Pediatric Research·Qing YangAshima Madan
Jul 22, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claire GillauxMichelle Breuiller-Fouché

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