A Spotlight on Rad52 in Cyanidiophytina (Rhodophyta): A Relic in Algal Heritage

Plants
Angelo Del MondoClaudia Ciniglia

Abstract

The RADiation sensitive52 (RAD52) protein catalyzes the pairing between two homologous DNA sequences' double-strand break repair and meiotic recombination, mediating RAD51 loading onto single-stranded DNA ends, and initiating homologous recombination and catalyzing DNA annealing. This article reports the characterization of RAD52 homologs in the thermo-acidophilic Cyanidiophyceae whose genomes have undergone extensive sequencing. Database mining, phylogenetic inference, prediction of protein structure and evaluation of gene expression were performed in order to determine the functionality of the RAD52 protein in Cyanidiophyceae. Its current function in Cyanidiophytina could be related to stress damage response for thriving in hot and acidic environments as well as to the genetic variability of these algae, in which, conversely to extant Rhodophyta, sexual mating was never observed.

References

Apr 1, 1968·Journal of General Microbiology·M M Allen, R Y Stanier
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·U H MortensenR Rothstein
Feb 12, 1999·Nucleic Acids Research·L AravindE V Koonin
Dec 15, 2000·Trends in Ecology & Evolution·Z Yang, J P Bielawski
Nov 10, 2001·Annual Review of Genomics and Human Genetics·M Kreitman
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Martin R SingletonDale B Wigley
Nov 29, 2002·Microbiology and Molecular Biology Reviews : MMBR·Lorraine S Symington
Aug 13, 2003·Bioinformatics·Fredrik Ronquist, John P Huelsenbeck
Jan 7, 2004·Biochemical and Biophysical Research Communications·Aleksandar RadonićAndreas Nitsche
Apr 9, 2004·Nature·Motomichi MatsuzakiTsuneyoshi Kuroiwa
Jun 11, 2004·Molecular Ecology·Claudia CinigliaDebashish Bhattacharya
Mar 10, 2006·PLoS Biology·Catriona MacCallum, Emma Hill
Jun 21, 2006·BMC Plant Biology·Christian Roth, David A Liberles
Sep 12, 2007·Bioinformatics·M A LarkinD G Higgins
Aug 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Juan Lucas ArguesoMichael A Resnick
Oct 15, 2008·Systematic Biology·Alexandros StamatakisJacques Rougemont
Feb 4, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Patrick J Keeling
Aug 25, 2010·Biology Direct·Jeferson Gross, Debashish Bhattacharya
Mar 14, 2012·Environmental Science and Pollution Research International·Claudia CinigliaMarco d'Ischia
Apr 18, 2012·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Anton BankevichPavel A Pevzner
Oct 12, 2013·Current Biology : CB·Huan QiuDebashish Bhattacharya
May 9, 2016·Plant Physiology and Biochemistry : PPB·Anuradha NairRajani Kant Chittela
May 21, 2018·Extremophiles : Life Under Extreme Conditions·Manuela IovinellaClaudia Ciniglia

❮ Previous
Next ❯

Citations

Sep 22, 2020·AMB Express·Dora Allegra CarboneMichael Melkonian
Feb 16, 2020·Applied Microbiology and Biotechnology·Dora Allegra CarboneMichael Melkonian

❮ Previous
Next ❯

Datasets Mentioned

BETA
M2XIH5

Methods Mentioned

BETA
electrophoresis
PCR

Software Mentioned

TASSER
Selecton
ClustalW
Spades
RAxML
JMolwas
BLAST
MrBayes

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved