A spurious markedly increased serum estradiol level due to an IgA lambda.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
D L GordonM H Brooks

Abstract

To alert physicians about the potential for erroneous laboratory determinations of hormone levels and emphasize the need to assess the overall clinical situation as well. We present a case report of a woman with a dramatically increased serum estradiol (E(2)) level on radioimmunoassay and review the studies that led to the conclusion that this laboratory finding did not reflect her true estrogen status. In a 41-year-old woman, an unnecessary surgical procedure was performed because of a falsely increased serum E(2) level and a unilateral ovarian mass. The markedly increased serum E(2) measured by radioimmunoassay was found to be attributable to an IgA lambda that bound to the 125 I-labeled tracer of the assay. When repeatedly abnormal hormone levels and the clinical picture seem discrepant, use of a different assay method should be considered.

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Citations

Feb 16, 2021·Archives of Endocrinology and Metabolism·Paul AtkinsDavid Thompson

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