A stabilising factor for gamma-glutamyl transpeptidase in urine

Clinica Chimica Acta; International Journal of Clinical Chemistry
P R Beck, H G Sammons

Abstract

Urinary gamma-glutamyl transpeptidase (gamma-GT) has been found to be stable when stored at room temperature and 4 degrees C. Activity is lost rapidly when urine is frozen but prior dialysis will prevent this loss. Urea is the major factor responsible for the loss of activity; albumin is protective at concentrations of 6 g/l or more. A factor of 10 000-30 000 molecular weight which will prevent the loss of urinary gamma-GT activity on freezing has been found in serum and urine; it has high potency in serum and in urine from patients with chronic renal failure, but only low potency in normal urine. Its nature is unknown but it is heat stable.

Citations

Jul 1, 1986·Archives of Environmental Contamination and Toxicology·P W MuellerK K Steinberg
Jan 1, 1988·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M Gumbleton, P J Nicholls
Jul 1, 1977·British Journal of Obstetrics and Gynaecology·M C NobleJ M Davison
Mar 1, 1978·British Journal of Obstetrics and Gynaecology·A M KellyH P McEwan
Dec 1, 1978·British Journal of Obstetrics and Gynaecology·A M Kelly, H P McEwan
Jan 1, 1982·Annals of Clinical Biochemistry·P G ShakespeareA H Futerman

Related Concepts

Albumins
Blood
Physical Dialysis
Drug Stability
Edetic Acid, Calcium, Sodium Salt
Melting
Gamma-glutamyl transferase
Kidney Failure, Chronic
Ultrafiltration

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