A stage-specific enhancer of immunoglobulin J chain gene is induced by interleukin-2 in a presecretor B cell stage

Immunity
C J KangM E Koshland

Abstract

Interleukin-2 (IL-2)-induced transcription of the J chain gene was used as a model for analyzing cytokine regulation during B cell development. To determine whether IL-2 signals are targeted to a J chain gene enhancer as well as to its promoter, the sequences flanking the J chain gene were first examined for DNase I hypersensitivity. Of six sites identified, two strong ones, 7.5 kb upstream of the J chain gene, were found to be associated with an enhancer that is active only during the antigen-driven stages of B cell development. Further analyses of the enhancer in the IL-2-responsive presecretor BCL1 cells showed that the enhancer is activated at this stage by an IL-2 signal that functions by opening the enhancer chromatin and stimulating STAT5 to bind to a STAT5 element critical for the enhancer induction. Moreover, after this early induction stage, the enhancer was shown to be constitutively open and active in terminally differentiated plasma cells.

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Citations

Mar 24, 2004·Trends in Immunology·Finn-Eirik Johansen, Per Brandtzaeg
Aug 30, 2001·Trends in Immunology·P Kourilsky, P Truffa-Bachi
Dec 3, 1999·Immunological Reviews·P BrandtzaegT Yamanaka
Dec 4, 2003·Molecular and Cellular Biology·Sophie MagnéIsabelle Dusanter-Fourt
Aug 2, 2008·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·V B KlimovichB V Klimovich
Sep 9, 2009·Biochimica Et Biophysica Acta·Sung-Kyun ParkChang-Joong Kang
Nov 18, 2005·Biochemical and Biophysical Research Communications·Sun-Jung Cho, Chang-Joong Kang
Sep 5, 1998·Immunity·J J BirdS L Reiner
Jul 29, 2005·Immunological Reviews·Per Brandtzaeg, Finn-Eirik Johansen
Jul 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xing-Cheng WeiAtsushi Muraguchi
Jul 10, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xuezhi DaiDemin Wang
Oct 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jung-Hyun LimChang-Joong Kang

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