A standardized autopsy procurement allows for the comprehensive study of DIPG biology

Oncotarget
Madhuri KambhampatiJavad Nazarian

Abstract

Diffuse intrinsic pontine glioma (DIPG) is one of the least understood and most deadly childhood cancers. Historically, there has been a paucity of DIPG specimens for molecular analysis. However, due to the generous participation of DIPG families in programs for postmortem specimen donation, there has been a recent surge in molecular analysis of newly available tumor specimens. Collaborative efforts to share data and tumor specimens have resulted in rapid discoveries in other pediatric brain tumors, such as medulloblastoma, and therefore have the potential to shed light on the biology of DIPG. Given the generous gift of postmortem tissue donation from DIPG patients, there is a need for standardized postmortem specimen accrual to facilitate rapid and effective multi-institutional molecular studies.We developed and implemented an autopsy protocol for rapid procurement, documenting and storing these specimens. Sixteen autopsies were performed throughout the United States and Canada and processed using a standard protocol and inventory method, including specimen imaging, fixation, snap freezing, orthotopic injection, or preservation. This allowed for comparative clinical and biological studies of rare postmortem DIPG tissue specime...Continue Reading

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Citations

Apr 7, 2016·Nature Communications·Hamid NikbakhtJavad Nazarian
Sep 26, 2017·Palliative & Supportive Care·Katharine Rae LangeYasmin Khakoo
Mar 13, 2019·International Journal of Cancer. Journal International Du Cancer·Sabine MuellerAdam C Resnick
Oct 2, 2019·Journal of Neuro-oncology·Jared T AhrendsenSanda Alexandrescu
Dec 6, 2019·Cancer Metastasis Reviews·Wafaa M RashedMohamed Saad Zaghloul
Apr 17, 2019·Journal of Neuropathology and Experimental Neurology·Sulgi LeeJavad Nazarian
Mar 16, 2019·Frontiers in Oncology·John P WelbyDavid J Daniels
Jan 16, 2018·JCO Precision Oncology·David J PisapiaJuan Miguel Mosquera
Oct 17, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eshini PanditharatnaJavad Nazarian
May 1, 2021·Cancers·Laura EscuderoJoan Seoane

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Methods Mentioned

BETA
surgical resection
biopsies
xenograft

Software Mentioned

DIPG

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