PMID: 16615687Apr 18, 2006Paper

A statistical analysis of factors predisposing patients to heparin resistance

Perfusion
Tanee ChanChong Hee Lim

Abstract

Heparin resistance (HR) is occasionally encountered in cardiac surgery. The objective of this study is to identify possible factors predisposing patients to heparin resistance. Four hundred patients scheduled for elective cardiac surgery requiring the use of cardiopulmonary bypass (CPB) were enrolled in this study. Data collection included: demographic data, types of preoperative anticoagulant/antiplatelet therapy, preoperative haematological and biochemical laboratory results, medical condition, baseline activated clotting time (ACT) and infusion volume prior to heparinisation. Patients who require 5 mg/kg or more to achieve ACT greater than 400 seconds before CPB were considered to be heparin resistant. All data was tested with a preliminary univariate analysis and factors associated with HR (p value <0.05) were entered into a multivariate logistic regression analysis. Factors associated with HR with a p value <0.05 are considered predictors for HR. Thirty-two (8.0%) of the 400 patients fulfilled the criteria for HR. Preoperative heparin (p =0.025), low molecular weight heparin (p =0.049), plateletcount > or = 300,000/ml (p =0.022) and albumin plasma concentration < or = 35 g/dl 0, =0.044) are significantly associated with HR...Continue Reading

References

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Citations

Feb 15, 2013·Anesthesia and Analgesia·Alan Finley, Charles Greenberg
Jul 13, 2019·Current Pharmaceutical Design·Antonia-Therese Kietaibl, Sibylle Kietaibl
Nov 2, 2014·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Jiang WangHong Zheng
Feb 2, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Piotr KnapikTomasz Knapik
Jul 21, 2009·Journal of Cardiovascular Medicine·Hyun Ju JungJae Myeong Lee
Oct 19, 2017·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Allison J JonesRavi S Samraj
Sep 19, 2019·Journal of Cardiothoracic and Vascular Anesthesia·Suneel Ramesh Desai, Nian Chih Hwang
Jun 20, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Yoshikazu KimuraHidekuni Hidaka
Apr 27, 2012·Journal of Cardiothoracic and Vascular Anesthesia·Yvonne P J BoschBaheramsjah Mochtar

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