A statistical and biological response to an informatics appraisal of healthy aging gene signatures

Genome Biology
James A TimmonsPhilip J Atherton

Abstract

Jacob and Speed did not identify even a single example of a '150-gene-set' that was statistically significant at classifying Alzheimer's disease (AD) samples, or age in independent studies. We attempt to clarify the various misunderstandings, below.

References

Oct 2, 2007·Statistics in Medicine·I R KönigUNKNOWN German Stroke Study Collaboration
Apr 3, 2012·Journal of Alzheimer's Disease : JAD·Katie LunnonUNKNOWN AddNeuroMed Consortium
Feb 20, 2015·Brain : a Journal of Neurology·Stephanie J B VosPieter Jelle Visser

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