A statistical approach for determination of disk diffusion-based cutoff values for systematic characterization of wild-type and non-wild-type bacterial populations in antimicrobial susceptibility testing

Journal of Clinical Microbiology
Giorgia ValsesiaMichael Hombach

Abstract

In this study, we introduce a new approach for determination of epidemiologic cutoffs (ECOFFs) and resistant-population cutoffs (RCOFFs) based on receiver operating characteristic (ROC) curves. As an example, the method was applied for determination of ECOFFs for seven different beta-lactam antibiotics and wild-type populations of Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae. In addition, RCOFFs were determined for bacterial populations with defined resistance mechanisms ("resistotypes"), i.e., extended-spectrum beta-lactamase (ESBL)-positive E. coli, ESBL-positive K. pneumoniae, and ESBL-positive E. cloacae; AmpC cephalosporinase-positive E. coli and AmpC-positive K. pneumoniae; and broad-spectrum beta-lactamase (BSBL)-positive E. coli. RCOFFs and ECOFFs are instrumental for a systematic characterization of associations between resistotypes and wild-type populations.

References

Feb 1, 1992·Diagnostic Microbiology and Infectious Disease·M N BrundenB Kapik
Jul 1, 1990·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J D Williams
Nov 1, 1989·The Journal of Antimicrobial Chemotherapy·C RoyM Hermida
Jun 3, 1988·Science·J A Swets
Dec 1, 1974·The Journal of Infectious Diseases·C M Metzler, R M DeHaan
Mar 24, 2000·Diagnostic Microbiology and Infectious Disease·B A Craig
Feb 13, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D L Paterson
Feb 18, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·G KronvallM F Galas
Jul 3, 2003·The Journal of Antimicrobial Chemotherapy·Gunnar KahlmeterAlkiviadis Vatopoulos
Oct 15, 2005·Clinical Microbiology Reviews·David L Paterson, Robert A Bonomo
Apr 29, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J TurnidgeG Kronvall
Jul 17, 2007·Clinical Microbiology Reviews·John Turnidge, David L Paterson
Aug 2, 2007·The Annals of Pharmacotherapy·Katherine Yang, B Joseph Guglielmo
Dec 25, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·R CantónT M Coque
Feb 23, 2008·The Lancet Infectious Diseases·Johann D D Pitout, Kevin B Laupland
Feb 10, 2011·Standards in Genomic Sciences·Lars Snipen, David W Ussery
Mar 1, 2011·Diagnostic Microbiology and Infectious Disease·Patricia J SimnerUNKNOWN Canadian Antimicrobial Resistance Alliance (CARA)
Jun 3, 2011·Journal of Clinical Microbiology·Silke PolsfussMichael Hombach
Jun 7, 2011·International Journal of Antimicrobial Agents·Göran KronvallGunnar Kahlmeter
Nov 8, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jesús Rodríguez-BañoUNKNOWN Extended-Spectrum Beta-Lactamases–Red Española de Investigación en Patología Infecciosa/Grupo de Estudio de Infección Hospit
Nov 29, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·R LeclercqG Kahlmeter
Jan 24, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S PolsfussM Hombach
Mar 31, 2012·The Journal of Antimicrobial Chemotherapy·David M LivermoreNeil Woodford
Sep 8, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E MiróF Navarro
Nov 9, 2012·Journal of Clinical Microbiology·Julie BlackburnAnne-Marie Bourgault
Dec 6, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M HombachM Roos
Dec 13, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E BouzaUNKNOWN GEIDI and the COMIC study groups
Oct 18, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E MatuschekG Kahlmeter
May 20, 2014·Upsala Journal of Medical Sciences·Gunnar Kahlmeter
Aug 2, 2014·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Song HeFang-Hong Gong
Aug 8, 2014·Journal of Clinical Microbiology·Florian P MaurerMichael Hombach

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.