A step back in time: is there a place for older drugs in the treatment of dementia?

Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L P FriedUNKNOWN Cardiovascular Health Study Collaborative Research Group

The APOE-E4 allele and the risk of functional decline in a community sample of African American and white older adults

Nov 28, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·D G BlazerB Burchett

Dynamics of stability: the physiologic basis of functional health and frailty

Feb 28, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Lewis A Lipsitz

Prevalence and impact of medical comorbidity in Alzheimer's disease

Feb 28, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·P Murali DoraiswamyPeter J Neumann

A conceptual framework of frailty: a review

May 2, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Walter M Bortz

Antibody to amyloid beta protein alleviates impaired acquisition, retention, and memory processing in SAMP8 mice

Jun 20, 2002·Neurobiology of Learning and Memory·John E MorleyJames F Flood

A fall is a major event in the life of an older person

Jul 30, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·John E Morley

Low cognitive performance, comorbid disease, and task-specific disability: findings from a nationally representative survey

Jul 30, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Caroline S BlaumJersey Liang

Therapeutic potential in Alzheimer disease

Aug 13, 2002·Current Medicinal Chemistry·A D CashM A Smith

The interaction of cognitive and emotional status on subsequent physical functioning in older mexican americans: findings from the Hispanic established population for the epidemiologic study of the elderly

Sep 21, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Mukaila A RajiJames S Goodwin

Editorial: Something about frailty

Oct 31, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·John E MorleyDouglas K Miller

The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice

Feb 27, 2003·Journal of Neurochemistry·Susan A FarrJohn E Morley

Memantine in moderate-to-severe Alzheimer's disease

Apr 4, 2003·The New England Journal of Medicine·Barry ReisbergUNKNOWN Memantine Study Group

Antibody to beta-amyloid protein increases acetylcholine in the hippocampus of 12 month SAMP8 male mice

May 29, 2003·Life Sciences·Susan A FarrJohn E Morley

Donepezil is associated with delayed nursing home placement in patients with Alzheimer's disease

Jul 2, 2003·Journal of the American Geriatrics Society·David S GeldmacherJohn R Ieni

"Preemptive strike?": sarcopenia and nutritional intervention

Jul 17, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Margaret-Mary G Wilson

Cerebrometabolic abnormalities in Alzheimer's disease

Sep 25, 2003·Neurological Research·John P Blass

Mouse models of Alzheimer's disease: the long and filamentous road

Sep 25, 2003·Neurological Research·Amie L PhinneyDavid Westaway

Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice

Sep 25, 2003·Neurological Research·Gjumrakch AlievGeorge Perry

The treatment of Alzheimer's disease: success short of cure

Sep 25, 2003·Lancet Neurology·Kenneth RockwoodRaymond Tallis

Efflux of human and mouse amyloid beta proteins 1-40 and 1-42 from brain: impairment in a mouse model of Alzheimer's disease

Oct 3, 2003·Neuroscience·W A BanksJ E Morley

Molecular and cellular basis for anti-amyloid therapy in Alzheimer disease

Dec 6, 2003·Alzheimer Disease and Associated Disorders·Sam GandyJoseph Buxbaum

Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial

Jan 22, 2004·JAMA : the Journal of the American Medical Association·Pierre N TariotUNKNOWN Memantine Study Group

Therapy for extrapulmonary sarcoidosis

Aug 10, 2005·Seminars in Respiratory and Critical Care Medicine·Robert P Baughman, Elyse E Lower

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A step back in time: is there a place for older drugs in the treatment of dementia?

Abstract

References

Dihydroergotoxine: 6-mg versus 3-mg dosage in the treatment of senile dementia. Preliminary report

Mental decline in the elderly: pharmacotherapy (ergot alkaloids versus papaverine)

Effect on memory processing by D-cycloserine, an agonist of the NMDA/glycine receptor.

Lack of efficacy of hydergine in patients with Alzheimer's disease

A controlled double-blind study of high-dose dihydroergotoxine mesylate (Hydergine) in mild dementia

An ergot alkaloid preparation (Hydergine) in the treatment of presenile brain atrophy (Alzheimer's disease): case report

Double-blind clinical and psychologic study of ergoloid mesylates (Hydergine) in subjects with senile mental deterioration

An amyloid beta-protein fragment, A beta[12-28], equipotently impairs post-training memory processing when injected into different limbic system structures

Topography of a binding site for small amnestic peptides deduced from structure-activity studies: relation to amnestic effect of amyloid beta protein

Learning and memory in the SAMP8 mouse

The anatomy of the central control of posture: consistency and plasticity

Age-related changes in septal serotonergic, GABAergic and glutamatergic facilitation of retention in SAMP8 mice

Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens

Site-directed antisense oligonucleotide decreases the expression of amyloid precursor protein and reverses deficits in learning and memory in aged SAMP8 mice

Frailty in older adults: evidence for a phenotype

The APOE-E4 allele and the risk of functional decline in a community sample of African American and white older adults

Dynamics of stability: the physiologic basis of functional health and frailty

Prevalence and impact of medical comorbidity in Alzheimer's disease

A conceptual framework of frailty: a review

Antibody to amyloid beta protein alleviates impaired acquisition, retention, and memory processing in SAMP8 mice

A fall is a major event in the life of an older person

Low cognitive performance, comorbid disease, and task-specific disability: findings from a nationally representative survey

Therapeutic potential in Alzheimer disease

The interaction of cognitive and emotional status on subsequent physical functioning in older mexican americans: findings from the Hispanic established population for the epidemiologic study of the elderly

Editorial: Something about frailty

The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice

Memantine in moderate-to-severe Alzheimer's disease

Antibody to beta-amyloid protein increases acetylcholine in the hippocampus of 12 month SAMP8 male mice

Donepezil is associated with delayed nursing home placement in patients with Alzheimer's disease

"Preemptive strike?": sarcopenia and nutritional intervention

Cerebrometabolic abnormalities in Alzheimer's disease

Mouse models of Alzheimer's disease: the long and filamentous road

Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice

The treatment of Alzheimer's disease: success short of cure

Efflux of human and mouse amyloid beta proteins 1-40 and 1-42 from brain: impairment in a mouse model of Alzheimer's disease

Molecular and cellular basis for anti-amyloid therapy in Alzheimer disease

Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial

Therapy for extrapulmonary sarcoidosis

Citations

Alzheimer's disease: future treatments

Clinical update on nursing home medicine: 2008

The magic of exercise

Managing persons with dementia in the nursing home: high touch trumps high tech

Evidence rocks in long-term care, but does it roll?

Cognitive impairment

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