A stochastic model of the single photon response in Drosophila photoreceptors

Integrative Biology : Quantitative Biosciences From Nano to Macro
Konstantin NikolicChris Toumazou

Abstract

We present a quantitative model for the phototransduction cascade in Drosophila photoreceptors. The process consists of four stages: (1) light absorption by Rhodopsin, (2) signal amplification phase mediated by a G-protein coupled cascade, (3) closed/open state kinetics of the transient receptor potential (TRP) ion channels which regulate the ionic current in/out of the cell and (4) Ca regulated positive and negative feedbacks. The model successfully reproduces the experimental results for: single photon absorption "quantum bump" (QB), statistical features for QB (average shape, peak current average value and variance, the latency distribution, etc.), arrestin mutant behaviour, low extracellular Ca(2+) cases, etc. The TRP channel activity is modeled by a Monod-Wyman-Changeux (MWC) model for allosteric interaction, instead of using the usual ad hoc Hill equation. This approach allows for a plausible physical explanation of how Ca/calmodulin regulate the protein activity. The cooperative nature of the TRP channel activation leads to "dark current" suppression at the output allowing for reliable detection of a single photon. Stochastic simulations were produced by using the standard rate equations combined with the Poisson distrib...Continue Reading

References

Dec 5, 1969·Science·M J Kushmerick, R J Podolsky
Nov 25, 1994·Science·A Kiselev, S Subramaniam
Jan 25, 1996·Nature·D E Clapham
Feb 21, 1998·Current Biology : CB·R Ranganathan, E M Ross
Apr 4, 2000·The Journal of Physiology·S R HendersonR C Hardie
May 12, 2000·Nature Cell Biology·B CookB Minke
Jul 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·J Oberwinkler, D G Stavenga
Sep 15, 2001·Nature·R C Hardie, P Raghu
Mar 28, 2002·Physiological Reviews·Baruch Minke, Boaz Cook
May 4, 2002·Annual Review of Biophysics and Biomolecular Structure·Stuart McLaughlinDiana Murray
May 1, 1965·Journal of Molecular Biology·J MONODJ P CHANGEUX
Oct 16, 2003·Science's STKE : Signal Transduction Knowledge Environment·Vadim Y Arshavsky
Nov 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Georg NagelErnst Bamberg
Jun 4, 2005·Science·Jean-Pierre Changeux, Stuart J Edelstein
Jun 18, 2005·The Journal of Physiology·Craig Montell
Oct 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hana ChoWon-Kyung Ho
Apr 22, 2006·BMC Neuroscience·J H van Hateren, T D Lamb
Aug 18, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniela C PopescuBih-Hwa Shieh
Sep 23, 2006·The Journal of Physiology·Roger C Hardie
Sep 23, 2006·Nature Methods·Feng ZhangKarl Deisseroth
Nov 24, 2006·Investigative Ophthalmology & Visual Science·Trevor D Lamb, Edward N Pugh
Dec 8, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tao Wang, Craig Montell
Dec 13, 2006·Trends in Biochemical Sciences·Silvia Carrasco, Isabel Mérida
Jan 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Che H LiuRoger C Hardie
Apr 13, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sumathi SekaranMark W Hankins
May 10, 2007·Pflügers Archiv : European journal of physiology·Tao Wang, Craig Montell
May 25, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shahar FrechterBaruch Minke
Oct 10, 2007·Cell·Prashant MishraRama Ranganathan
Nov 2, 2007·Nature·Roger C Hardie
Dec 8, 2007·The Biochemical Journal·Isabel MéridaErnesto Merino

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Citations

Feb 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ben Katz, Baruch Minke
May 15, 2013·Biophysical Journal·Brian ChuRoger C Hardie
Feb 2, 2015·Current Opinion in Neurobiology·Roger C Hardie, Mikko Juusola
Jun 19, 2012·Current Biology : CB·Zhuoyi SongMikko Juusola
Sep 22, 2016·PeerJ·Pingkalai R Senthilan, Charlotte Helfrich-Förster
Apr 15, 2020·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Irina I IgnatovaRoman V Frolov
Oct 28, 2017·PLoS Computational Biology·Kris V Parag, Glenn Vinnicombe

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