A Stochastic Petri Net-Based Model of the Involvement of Interleukin 18 in Atherosclerosis.

International Journal of Molecular Sciences
Dorota FormanowiczPiotr Formanowicz

Abstract

Interleukin 18 (IL-18) is a proinflammatory and proatherogenic cytokine with pleiotropic properties, which is involved in T and NK cell maturation and the synthesis of other inflammatory cytokines and cell adhesion molecules. It plays a significant role in orchestrating the cytokine cascade, accelerates atherosclerosis and influences plaque vulnerability. To investigate the influence of IL-18 cytokine on atherosclerosis development, a stochastic Petri net model was built and then analyzed. First, MCT-sets and t-clusters were generated, then knockout and simulation-based analysis was conducted. The application of systems approach that was used in this research enabled an in-depth analysis of the studied phenomenon. Our results gave us better insight into the studied phenomenon and allow revealing that activation of macrophages by the classical pathway and IL-18-MyD88 signaling axis is crucial for the modeled process.

References

Feb 28, 2002·British Journal of Pharmacology·David J MacEwan
May 2, 2002·Kidney International. Supplement·Julia CarracedoPedro Aljama
Mar 27, 2003·Medical Electron Microscopy : Official Journal of the Clinical Electron Microscopy Society of Japan·Kiyoshi TakahashiNaomi Sakashita
Nov 13, 2003·Atherosclerosis·Stefan BlankenbergLaurence Tiret
Jan 31, 2004·Seminars in Immunology·Kiyoshi Takeda, Shizuo Akira
Feb 22, 2005·Molecular Aspects of Medicine·Khalid M Naseem
Apr 8, 2006·Physiological Reviews·Alain Tedgui, Ziad Mallat
Nov 4, 2006·BMC Bioinformatics·Andrea SackmannIna Koch
Nov 14, 2006·Computational Biology and Chemistry·Andrea SackmannJacek Blazewicz
Feb 9, 2008·BMC Bioinformatics·Eva Grafahrend-BelauIna Koch
Mar 29, 2008·Bio Systems·Stefanie GrunwaldIna Koch
Sep 9, 2008·Computational Biology and Chemistry·J KielbassaI Koch
Sep 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Virginia Vila-del SolManuel Fresno
Dec 15, 2010·Cell Research·Andy WullaertManolis Pasparakis
Aug 30, 2014·Cytokine & Growth Factor Reviews·Lisa M Sedger, Michael F McDermott
Dec 3, 2014·The American Journal of Pathology·Prajwal Gurung, Thirumala-Devi Kanneganti
Aug 27, 2015·World Journal of Experimental Medicine·Joe We Moss, Dipak P Ramji
Jul 1, 2016·Future Medicinal Chemistry·Joe We Moss, Dipak P Ramji
Dec 5, 2016·Biochemistry. Biokhimii︠a︡·A R FatkhullinaE K Koltsova
Nov 22, 2017·Signal Transduction and Targeted Therapy·Ting LiuShao-Cong Sun
Aug 16, 2018·Frontiers in Oncology·Emira Bousoik, Hamidreza Montazeri Aliabadi
Nov 8, 2018·International Journal of Molecular Sciences·Dorota FormanowiczPiotr Formanowicz
Sep 27, 2019·Frontiers in Immunology·Jennifer KreckelHarald Wajant
May 14, 2020·International Journal of Molecular Sciences·Dorota FormanowiczPiotr Formanowicz

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