A stoichiometry driven universal spatial organization of backbones of folded proteins: are there Chargaff's rules for protein folding?

Journal of Biomolecular Structure & Dynamics
Aditya MittalTejdeep Singh Bawa

Abstract

Protein folding is at least a six decade old problem, since the times of Pauling and Anfinsen. However, rules of protein folding remain elusive till date. In this work, rigorous analyses of several thousand crystal structures of folded proteins reveal a surprisingly simple unifying principle of backbone organization in protein folding. We find that protein folding is a direct consequence of a narrow band of stoichiometric occurrences of amino-acids in primary sequences, regardless of the size and the fold of a protein. We observe that "preferential interactions" between amino-acids do not drive protein folding, contrary to all prevalent views. We dedicate our discovery to the seminal contribution of Chargaff which was one of the major keys to elucidation of the stoichiometry-driven spatially organized double helical structure of DNA.

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Citations

Jul 4, 2012·Journal of Biosciences·Aditya Mittal, B Jayaram
Feb 8, 2011·Journal of Biomolecular Structure & Dynamics·Sujata Roy, Ashoke Ranjan Thakur
May 2, 2012·Journal of Biomolecular Structure & Dynamics·Subhojyoti ChatterjeeSaraswathi Vishveshwara
May 11, 2012·Journal of Biomolecular Structure & Dynamics·Riddhi MajumderAshoke Ranjan Thakur
Aug 1, 2012·Journal of Biomolecular Structure & Dynamics·Subramaniam Boopathi, Ponmalai Kolandaivel
Jan 10, 2013·Journal of Biomolecular Structure & Dynamics·Aditya Mittal, Chanchal Acharya
Jan 16, 2013·Journal of Biomolecular Structure & Dynamics·Paul S Agutter
Jan 10, 2013·Journal of Biomolecular Structure & Dynamics·Teodorico C RamalhoElaine F F da Cunha
Feb 9, 2013·Journal of Biomolecular Structure & Dynamics·A Kaushik, D Gupta
Jul 27, 2014·Biochimica Et Biophysica Acta·Avinash MishraB Jayaram
May 15, 2013·Biochimica Et Biophysica Acta·Avinash MishraB Jayaram
Feb 21, 2014·Science China. Life Sciences·HuiMin LiShuQun Liu
Jan 10, 2013·Journal of Biomolecular Structure & Dynamics·Jing YanLukasz Kurgan
Jan 30, 2015·Molecular Biology of the Cell·Suneyna Bansal, Aditya Mittal
Mar 15, 2014·Journal of Biomolecular Structure & Dynamics·K M Saravanan, S Krishnaswamy
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Apr 8, 2011·Journal of Biomolecular Structure & Dynamics·Vinod JaniRajendra Joshi
Apr 3, 2020·Journal of Biomolecular Structure & Dynamics·Aditya MittalIshan Singh
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Dec 15, 2010·Journal of Biomolecular Structure & Dynamics·Paul S Agutter
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