PMID: 9536445Apr 16, 1998Paper

A strain-dependent ratchet model for [phosphate]- and [ATP]-dependent muscle contraction

Journal of Muscle Research and Cell Motility
D A Smith

Abstract

A minimal strain-dependent ratchet model of muscle cross-bridge action is proposed which is broadly compatible with structural and kinetic constraints. Its essential features are: (1) dynamic binding of the S1-products complex to actin through a disorder-order transition coupled to the release of inorganic phosphate; (2) the absence of a force-generating rotation of the myosin head between the two force-holding states A.M.ADP and A.M; (3) strain-control of ADP release and ATP binding, giving net isometric tension and directed motility by the selective dissociation of negatively strained bound states. With a disordered pre-force state, the binding rate to state A.M.ADP need not be symmetric in x, the actin site displacement. With faster binding at positive x, the model predicts many steady-state and transient properties of striated muscle observed experimentally, including phases 2-4 of tension recovery from length changes and their dependence on excess phosphate (which enhances and accelerates phase 3) and reduced ATP (which gives a bimodal phase 2 and slows one mode). The response to large perturbations is often sensitive to the number of actin sites used, and to the inclusion of a 1 nm displacement of the neck region on relea...Continue Reading

Citations

Dec 23, 2004·Journal of Molecular Histology·Edmund J CrampinPeter J Hunter
Apr 22, 2008·Journal of Muscle Research and Cell Motility·Masataka Kawai, Herbert R Halvorson
May 29, 2008·Annals of Biomedical Engineering·D A Smith, S M Mijailovich
Dec 9, 2015·Annual Review of Biomedical Engineering·V Y WangM P Nash
Nov 25, 2004·Progress in Biophysics and Molecular Biology·Nicholas P SmithDenis S Loiselle
May 15, 2004·Progress in Biophysics and Molecular Biology·Andrew PullanMartin Buist
Feb 13, 2021·Journal of Muscle Research and Cell Motility·Masataka Kawai, Jian-Ping Jin

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