A strategy to control transmission of Schistosoma japonicum in China

The New England Journal of Medicine
Long-De WangXiao-Nong Zhou

Abstract

Schistosoma japonicum causes an infection involving humans, livestock, and snails and is a significant cause of morbidity in China. We evaluated a comprehensive control strategy in two intervention villages and two control villages along Poyang Lake in the southeastern province of Jiangxi, where annual synchronous chemotherapy is routinely used. New interventions, implemented from 2005 through 2007, included removing cattle from snail-infested grasslands, providing farmers with mechanized farm equipment, improving sanitation by supplying tap water and building lavatories and latrines, providing boats with fecal-matter containers, and implementing an intensive health-education program. During the intervention period, we observed changes in S. japonicum infection in humans, measured the rate of infection in snails, and tested the infectivity of lake water in mice. After three transmission seasons, the rate of infection in humans decreased to less than 1.0% in the intervention villages, from 11.3% to 0.7% in one village and from 4.0% to 0.9% in the other (P<0.001 for both comparisons). The rate of infection in humans in control villages fluctuated but remained at baseline levels. In intervention villages, the percentage of samplin...Continue Reading

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Citations

Oct 12, 2012·Parasitology Research·Wei WangYou-Sheng Liang
May 1, 2013·Veterinary Parasitology·Paul R Torgerson
Apr 6, 2012·Lancet·Justin V Remais, Joseph N S Eisenberg
Jun 12, 2013·Lancet·Hon-Ming LamSamuel Sai-Ming Sun
Jan 9, 2009·The New England Journal of Medicine·Charles H King
Nov 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ricardo J Soares MagalhãesArchie C A Clements
Jun 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·James W RudgeMaría-Gloria Basáñez
Jun 27, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Moses J BockarieDavid H Molyneux
Apr 9, 2010·Clinical Microbiology Reviews·Donald P McManusAllen G Ross
Jul 11, 2009·Parasites & Vectors·Li-Guang TianXiao-Nong Zhou
Jun 16, 2011·Parasites & Vectors·David MolyneuxDeborah Kioy
Nov 4, 2011·Parasites & Vectors·You-Sheng LiangJian-Rong Dai
Nov 30, 2012·Parasites & Vectors·Humphrey D MazigoDavid W Dunne
Jan 1, 2012·Infectious Diseases of Poverty·Charles CollinsShenglan Tang
Jul 31, 2013·Infectious Diseases of Poverty·Qi ZhengHao-Bing Zhang
Jan 27, 2011·PLoS Neglected Tropical Diseases·Jing XuXiao-Nong Zhou
Nov 1, 2011·PLoS Neglected Tropical Diseases·Edmund Y W SetoXiao-Nong Zhou
Nov 21, 2012·PLoS Neglected Tropical Diseases·Bin XuZheng Feng
May 9, 2014·PLoS Neglected Tropical Diseases·Shi-Zhu LiXiao-Nong Zhou

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