A stress reaction affects assessment of selectivity of adrenal venous sampling and of lateralization of aldosterone excess in primary aldosteronism

European Journal of Endocrinology
Teresa M SecciaGian Paolo Rossi

Abstract

A stress reaction involving increased cortisol release, which has not been documented thus far, might affect the assessment of selectivity of catheterization during adrenal venous sampling (AVS). To investigate whether an ACTH-driven cortisol release occurs during AVS and whether it influences the assessment of selectivity by the step-up of cortisol (plasma cortisol concentrations, PCC) between the adrenal vein blood (PCC(SIDE)) and the inferior vena cava (PCC(IVC)), e.g. the selectivity index (SI). We determined the SI in samples obtained simultaneously at starting AVS (t-15) and again after 15  min (t0) in 34 consecutive patients with proven aldosterone-producing adenoma. We then calculated the SI with PCC(SIDE) obtained at t-15 and at t0, and the PCC(IVC) values obtained at the different time point, thus simulating sequential AVS. The PCC(SIDE) and the SI fell significantly from t-15 to t0 on both the sides. When PCC(SIDE) obtained at t-15 was combined with PCC(IVC) at t0, the SI values were higher than those obtained with simultaneously drawn samples. This led to label as selective more AVS studies than with bilaterally simultaneous data, especially when using higher cutoffs for the SI. A transient increase in cortisol rele...Continue Reading

References

Mar 1, 1979·Annals of Internal Medicine·M H WeinbergerJ P Donohue
Feb 1, 1996·Radiology·J L Doppman, J R Gill
Nov 5, 2004·Journal of Vascular and Interventional Radiology : JVIR·Caitlin E CarrScott O Trerotola
Jan 20, 2005·Surgery·William F YoungJon A van Heerden
Oct 18, 2005·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Nicholas Daunt
Dec 13, 2006·Journal of the American College of Cardiology·Gian Paolo RossiUNKNOWN PAPY Study Investigators
Mar 11, 2008·Journal of Hypertension·Gian Paolo RossiAnthony M Heagerty
Jun 17, 2008·The Journal of Clinical Endocrinology and Metabolism·John W FunderUNKNOWN Endocrine Society
Dec 4, 2008·European Journal of Endocrinology·Masayuki TanemotoSadayoshi Ito
Jan 9, 2009·Clinical Endocrinology·William F Young, Anthony W Stanson
Sep 23, 2009·Clinical Endocrinology·Paul M Stewart, Bruno Allolio
Jan 12, 2010·The Journal of Clinical Endocrinology and Metabolism·E Marie FreelWilliam F Young
Apr 23, 2010·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R J AuchusF E Nwariaku
Jul 29, 2010·Current Hypertension Reports·Gian Paolo Rossi
Feb 18, 2011·The Journal of Clinical Endocrinology and Metabolism·Teresa M SecciaGian Paolo Rossi
May 26, 2011·Nature Reviews. Endocrinology·Gian Paolo Rossi
Jun 22, 2011·Nature Reviews. Endocrinology·Klara J Rosenquist, Robert G Dluhy

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Citations

Apr 3, 2016·Annales d'endocrinologie·Stéphane BardetOlivier Steichen
Apr 17, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tanja DekkersJaap Deinum
Nov 12, 2016·European Journal of Endocrinology·Mohamed-Karji AlmarzooqiEric Therasse
Jan 12, 2017·Japanese Journal of Radiology·Yuya KoikeTetsuo Nishikawa
Apr 20, 2017·International Journal of Molecular Sciences·Fabrizio BuffoloPaolo Mulatero
Mar 10, 2018·Current Opinion in Endocrinology, Diabetes, and Obesity·Gian Paolo Rossi
Sep 13, 2017·Journal of Clinical Pathology·Gregory Kline, Daniel T Holmes
Oct 2, 2013·Hypertension·Tanja DekkersGraeme Eisenhofer
Apr 28, 2016·Current Opinion in Endocrinology, Diabetes, and Obesity·Olivier Steichen, Laurence Amar
Apr 11, 2013·Current Opinion in Endocrinology, Diabetes, and Obesity·Barry A SacksIan M Brennan
Dec 6, 2019·Endocrine Journal·Arina MiyoshiSatoshi Terae
Aug 28, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Sofia M DickSandra P Silveiro
Nov 1, 2012·Expert Review of Endocrinology & Metabolism·Tetsuo NishikawaYoko Matsuzawa
Oct 23, 2021·Endocrinology and Metabolism·Mitsuhide NaruseMasakatsu Sone

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