A strong association between HLA-DR9 and gelatin allergy in the Japanese population

Vaccine
T KumagaiA Wakisaka

Abstract

The frequency of HLA class I and II phenotypes was determined among 23 patients with positive gelatin IgE, eight of whom developed anaphylaxis, 18 patients who did not have gelatin IgE but who experienced non-immediate reactions after exposure to gelatin. HLA-DR9, which is unique to Orientals, was present in 56.5% of the gelatin IgE positive patients, as compared to control population frequency of 24% (P < 0.002). In the non-immediate reaction group, who did not generate IgE, phenotype distribution resembled controls. HLA-DR9 positive individuals have a relative risk of 4.1 for developing gelatin allergy with positive IgE.

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Citations

May 25, 2002·Allergy·Christoph Grüber, B Niggemann
Jul 30, 2002·Tissue Antigens·M SakaguchiS Inouye
Oct 10, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T KumagaiS Yano
Apr 1, 2005·American Journal of Clinical Dermatology·Arjen F NikkelsGerald E Piérard
Jun 11, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Julie Wang, Scott H Sicherer
Oct 18, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Jean-Christoph CaubetPhilippe A Eigenmann
Jun 1, 2014·The Journal of Allergy and Clinical Immunology·John M Kelso
Apr 9, 2015·Clinical and Translational Medicine·Fabrizio FranceschiniCarlo Caffarelli
Aug 3, 2007·Expert Review of Vaccines·Sofia Kalaboka, Isabella Annesi-Maesano
May 27, 2014·The Tohoku Journal of Experimental Medicine·Jae-Woo JungHye-Ryun Kang
Aug 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eddie A JamesWilliam W Kwok

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Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.