A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

Science
Y MikiW Ding

Abstract

A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods. Probable predisposing mutations have been detected in five of eight kindreds presumed to segregate BRCA1 susceptibility alleles. The mutations include an 11-base pair deletion, a 1-base pair insertion, a stop codon, a missense substitution, and an inferred regulatory mutation. The BRCA1 gene is expressed in numerous tissues, including breast and ovary, and encodes a predicted protein of 1863 amino acids. This protein contains a zinc finger domain in its amino-terminal region, but is otherwise unrelated to previously described proteins. Identification of BRCA1 should facilitate early diagnosis of breast and ovarian cancer susceptibility in some individuals as well as a better understanding of breast cancer biology.

References

Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M H LittleN D Hastie
Jul 13, 1991·Lancet·S A NarodG M Lenoir
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M LovettL M Hinton
Dec 26, 1991·The New England Journal of Medicine·M SwiftC L Chase
Jun 1, 1990·American Journal of Epidemiology·C MettlinW Lane
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R PatarcaK A Johnson
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G WestinU Pettersson
Mar 25, 1981·Journal of Molecular Biology·T F Smith, M S Waterman
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R LoveringP S Freemont
Jan 1, 1994·IMA Journal of Mathematics Applied in Medicine and Biology·A Thomas, M H Skolnick
Oct 7, 1994·Science·P A FutrealY Miki
Jan 1, 1993·Journal of Cellular Biochemistry. Supplement·H S SmithM Lagios
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·J Weaver-FeldhausA Kamb
Apr 1, 1994·Human Molecular Genetics·I G CampbellE Solomon
Feb 2, 1994·Journal of the National Cancer Institute·D E GoldgarM H Skolnick

❮ Previous
Next ❯

Citations

Jul 1, 1996·Journal of Surgical Oncology·K S Hughes, C A Roche
May 14, 1998·Journal of Surgical Oncology·G B Mann, P I Borgen
Jun 1, 1996·Cancer·E B ClausN J Risch
May 24, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·N GaliliC A Buck
Jan 26, 1996·International Journal of Cancer. Journal International Du Cancer·J PetoA J Swerdlow
Mar 1, 1996·International Journal of Cancer. Journal International Du Cancer·A TicherI E Ashkenazi
Apr 22, 1997·International Journal of Cancer. Journal International Du Cancer·R InoueM Nagao
May 29, 1997·International Journal of Cancer. Journal International Du Cancer·P D PharoahB A Ponder
Dec 16, 1997·International Journal of Cancer. Journal International Du Cancer·S RibierasR Dante
Jul 29, 1998·International Journal of Cancer. Journal International Du Cancer·S FanE M Rosen
Aug 12, 1998·International Journal of Cancer. Journal International Du Cancer·J TaylorS Ali
Aug 4, 1998·International Journal of Cancer. Journal International Du Cancer·D J Bernard-GallonY J Bignon
Feb 13, 1999·International Journal of Cancer. Journal International Du Cancer·T UchidaK Koshiba
Aug 17, 1999·International Journal of Cancer. Journal International Du Cancer·M SantarosaA Viel
Oct 3, 1999·International Journal of Cancer. Journal International Du Cancer·O DíezM Baiget
Mar 4, 2000·International Journal of Cancer. Journal International Du Cancer·E SpitzerR Grosse
May 8, 2000·International Journal of Cancer. Journal International Du Cancer·D Bernard-GallonY J Bignon
Nov 20, 1997·Journal of Cellular Physiology·S KalantryP P Pandolfi
Oct 21, 1999·Journal of Cellular Physiology·Y ChenH K Chew
Jan 1, 1996·Genetic Epidemiology·M E ParentA Lacroix
Jan 1, 1996·Genetic Epidemiology·D F BarkerH Anton-Culver
May 21, 1998·Genetic Epidemiology·K Hemminki, P Vaittinen
May 14, 1999·Genetic Epidemiology·A G SchwartzG M Swanson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.