A strong impact of matching for a limited number of HLA-DR antigens on graft survival and rejection episodes: a single-center study of first cadaveric kidneys to nonsensitized recipients

Transplantation
A V ReisaeterE Thorsby

Abstract

A single-center study of 655 nonsensitized recipients of primary cadaveric kidney grafts is presented. Graft survival in serologically HLA-DR 1-10 antigen-matched grafts to nonsensitized recipients at 1 year was 90%, compared with 82% (P=0.004) and 73% (P=0.001) in one and two DR antigen-mismatched grafts. The corresponding figures at 5 years were 76%, 62%, and 56%, respectively. Matching for the DR antigens 11-14, or for some DR alleles only detectable by genomic typing, further improved graft survival, but the differences did not reach statistical significance. Matching also for the serologically defined HLA-A and -B antigens did not significantly further improve overall graft survival, but some effects for grafts surviving at least 1 year were observed. Among recipients of grafts mismatched for zero, one, or two HLA-DR antigens, acute rejection episodes were experienced in 48%, 64% (P<0.001), and 82% (P<0.001), respectively, within the first 3 months. HLA-A and -B mismatches showed no significant correlation to acute rejection episodes. Matching for the DR antigens 1-10 significantly secures and prolongs the survival of first cadaveric renal grafts. Our results also show that DR 1-10 antigen-matched combinations can often be...Continue Reading

References

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Citations

Mar 20, 1999·Transplantation Proceedings·E Thorsby
Oct 24, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Solbjørg SagedalHalvor Rollag
May 14, 2004·The New England Journal of Medicine·Erik Thorsby, Per F Pfeffer
Jan 28, 2003·Transplantation·Yvo W J SijpkensLeendert C Paul
Mar 19, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Philipp C NettHans W Sollinger
Feb 22, 2017·Transplantation·Malek KamounRobert M Merion
Sep 21, 2011·Tissue Antigens·E Thorsby
Oct 21, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S SundT Hovig
Jul 1, 2014·Current Opinion in Organ Transplantation·Chris Wiebe, Peter Nickerson
Oct 30, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C WiebeP W Nickerson
Jun 7, 2014·Molecular Biology Reports·Behrouz Gharesi-FardJamshid Roozbeh
Jun 8, 2021·Stem Cells International·Yoo-Wook KwonHyo-Soo Kim

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