A strong nonequilibrium bound for sorting of cross-linkers on growing biopolymers.

Proceedings of the National Academy of Sciences of the United States of America
Yuqing QiuSuriyanarayanan Vaikuntanathan

Abstract

Understanding the role of nonequilibrium driving in self-organization is crucial for developing a predictive description of biological systems, yet it is impeded by their complexity. The actin cytoskeleton serves as a paradigm for how equilibrium and nonequilibrium forces combine to give rise to self-organization. Motivated by recent experiments that show that actin filament growth rates can tune the morphology of a growing actin bundle cross-linked by two competing types of actin-binding proteins [S. L. Freedman et al., Proc. Natl. Acad. Sci. U.S.A. 116, 16192-16197 (2019)], we construct a minimal model for such a system and show that the dynamics of a growing actin bundle are subject to a set of thermodynamic constraints that relate its nonequilibrium driving, morphology, and molecular fluxes. The thermodynamic constraints reveal the importance of correlations between these molecular fluxes and offer a route to estimating microscopic driving forces from microscopy experiments.

References

Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J J Hopfield
Dec 1, 1996·Biophysical Journal·A Mogilner, G Oster
Dec 15, 2007·Science·Dimitrios VavylonisThomas D Pollard
Jul 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·David Andrieux, Pierre Gaspard
Jul 10, 2008·Journal of Mathematical Biology·Richard B Dickinson
Aug 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yuhai Tu
Jul 7, 2009·Annual Review of Cell and Developmental Biology·Margaret L GardelClare M Waterman
Mar 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Julian Weichsel, Ulrich S Schwarz
Mar 15, 2011·The European Physical Journal. E, Soft Matter·U Seifert
Jun 28, 2012·Nature Physics·Ganhui LanYuhai Tu
Jul 13, 2012·Proceedings of the National Academy of Sciences of the United States of America·Arvind MuruganStanislas Leibler
Aug 3, 2014·The Journal of Chemical Physics·P Gaspard, D Andrieux
May 2, 2015·Physical Review Letters·Andre C Barato, Udo Seifert
Jul 2, 2015·Nature Reviews. Molecular Cell Biology·Michael MurrellMargaret L Gardel
Nov 14, 2015·Nature Physics·Yuansheng CaoYuhai Tu
Apr 9, 2016·Physical Review Letters·Todd R GingrichJeremy L England
Dec 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Michael Nguyen, Suriyanarayanan Vaikuntanathan
Aug 2, 2017·Chemical Society Reviews·Jie ZhangSteve Granick
Sep 28, 2017·Nature Communications·Dennis ZimmermannDavid R Kovar
Jan 20, 2019·Proceedings of the National Academy of Sciences of the United States of America·Jenny M PoultonThomas E Ouldridge
Jul 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Simon L FreedmanGlen M Hocky
Feb 6, 2020·Proceedings of the National Academy of Sciences of the United States of America·Samuel J Bryant, Benjamin B Machta
Feb 10, 2020·The Journal of Chemical Physics·Clara Del Junco, Suriyanarayanan Vaikuntanathan
Feb 20, 2020·Physical Review. E·Clara Del Junco, Suriyanarayanan Vaikuntanathan
Apr 24, 2020·Nature Physics·Sebastian FürthauerMichael J Shelley
May 2, 2020·Proceedings of the National Academy of Sciences of the United States of America·James LimanMargaret S Cheung
Oct 7, 2020·Annual Review of Cell and Developmental Biology·Rachel S KadzikDavid R Kovar
Nov 8, 2020·Current Opinion in Cell Biology·Antoine Jégou, Guillaume Romet-Lemonne
Feb 20, 2021·Physical Review. E·Trevor GrandPreDavid T Limmer

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Actin-binding Proteins

Actin-binding proteins are a component of the actin cytoskeleton that play essential roles in cellular functions such as regulation of actin polymerization, maintenance of cell polarity, gene expression regulation, cell motility and many more functions. Discover the latest research on actin-binding proteins here.

Related Papers

The Journal of Physical Chemistry. B
F Ritort
Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics
Y V KalyuzhnyiH D Cochran
Proceedings of the National Academy of Sciences of the United States of America
Qiong Liu, Jin Wang
© 2021 Meta ULC. All rights reserved