A strontium-incorporated nanoporous titanium implant surface for rapid osseointegration

Nanoscale
Wenjie ZhangXinquan Jiang

Abstract

Rapid osseointegration of dental implants will shorten the period of treatment and enhance the comfort of patients. Due to the vital role of angiogenesis played during bone development and regeneration, it might be feasible to promote rapid osseointegration by modifying the implant surface to gain a combined angiogenesis/osteogenesis inducing capacity. In this study, a novel coating (MAO-Sr) with strontium-incorporated nanoporous structures on titanium implants was generated via a new micro-arc oxidation, in an attempt to induce angiogenesis and osteogenesis to enhance rapid osseointegration. In vitro, the nanoporous structure significantly enhanced the initial adhesion of canine BMSCs. More importantly, sustained release of strontium ions also displayed a stronger effect on the BMSCs in facilitating their osteogenic differentiation and promoting the angiogenic growth factor secretion to recruit endothelial cells and promote blood vessel formation. Advanced mechanism analyses indicated that MAPK/Erk and PI3K/Akt signaling pathways were involved in these effects of the MAO-Sr coating. Finally, in the canine dental implantation study, the MAO-Sr coating induced faster bone formation within the initial six weeks and the osseointeg...Continue Reading

References

Jun 4, 1999·Progress in Biophysics and Molecular Biology·D D SchlaepferD J Sieg
Dec 16, 2005·Nature·Peter Carmeliet
Aug 15, 2006·Dental Materials : Official Publication of the Academy of Dental Materials·L Le GuéhennecY Amouriq
Jan 11, 2008·Proceedings of the National Academy of Sciences of the United States of America·Chao WanThomas L Clemens
May 6, 2008·European Cells & Materials·J M Kanczler, R O C Oreffo
Jan 31, 2009·Proceedings of the National Academy of Sciences of the United States of America·Seunghan OhSungho Jin
Oct 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Zahia HamidouchePierre J Marie
Dec 8, 2009·Biomaterials·Chye Khoon PohWilson Wang
Mar 11, 2010·Expert Review of Medical Devices·Carlos Nelson Elias, Luiz Meirelles
Jul 7, 2012·Tissue Engineering. Part B, Reviews·Lonnissa H NguyenAli Khademhosseini
Mar 22, 2014·Nature·Saravana K RamasamyRalf H Adams
Jul 22, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Wenjie ZhangXinquan Jiang
Jan 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jinhua LiChuanxian Ding

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Citations

Jan 17, 2017·Clinical Implant Dentistry and Related Research·Bingkun ChengLiang Kong
Jan 18, 2017·Dental Materials : Official Publication of the Academy of Dental Materials·A CarradòG Pourroy
Oct 13, 2017·Journal of Biomaterials Applications·Jiang HuanhuanShu Li
May 29, 2019·Journal of Dental Research·C ZhouF M He
Oct 13, 2018·Scientific Reports·Elvira De GiglioPiergiorgio Gentile
Sep 29, 2020·International Journal of Nanomedicine·Xiaodong LiLing Zhang
Nov 1, 2016·Journal of Biomedical Materials Research. Part a·Phaedra Silva-BermudezSandra E Rodil
Jan 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zheni GongZhihong Zhu
Jun 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mengfei YuHuiming Wang
May 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jie WangXinquan Jiang
May 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shuang WangYuanyuan Li
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Yao DingRuirui Liu
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Hao ZhangChunbo Tang
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·A I CostaA R Ribeiro
Mar 2, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Tianxiao HanQingsong Jiang
May 27, 2021·Advanced Healthcare Materials·Monika ŠalandováLidy E Fratila-Apachitei
Jun 18, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiexing WuLei Yang
Jul 3, 2021·Micromachines·Barbara SartoriBenedetta Marmiroli
Jul 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Li LiGang Wu
Jul 15, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Maowen ChenKaiyong Cai
Jun 16, 2018·ACS Applied Materials & Interfaces·Álvaro J LeiteJoão F Mano
Nov 10, 2018·ACS Applied Materials & Interfaces·Ji TanXuanyong Liu
Aug 9, 2019·Acta Biomaterialia·D BarbaR C Reed

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