A structural and functional comparison of staphylococcal enterotoxins A and C2 reveals remarkable similarity and dissimilarity

Journal of Molecular Biology
E SchadK R Acharya

Abstract

Staphylococcal enterotoxins and toxic shock syndrome toxin-1 are known as superantigens due to their ability to activate a large number of T-cells by crosslinking the major histocompatibility complex class II molecules with the T-cell receptor. Although superantigens seem to act by a common mechanism, they vary in many of their specific interactions and biological properties. A structural comparison of staphylococcal enterotoxins A and C2, members of the staphylococcal superantigens, has shown large conformational differences at the putative TcR interaction site (loops between alphaN-alpha2, alpha4-beta9 and beta10-alpha5 in staphylococcal enterotoxin A) that could explain the variability in their T-cell receptor specificity. A common Zn2(+)-binding site was identified in both staphylococcal enterotoxin A and C2 that is superimposable but differs somewhat in its coordination geometry between the two molecules.

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Citations

May 29, 2008·Journal of Industrial Microbiology & Biotechnology·Jing HuiFengqing Hu
Jun 24, 2015·Toxicology Mechanisms and Methods·Tiegang LiMin Zhao
Sep 27, 2008·Cancer Immunology, Immunotherapy : CII·Xiaogang WangChenggang Zhang
Dec 17, 2008·Applied Microbiology and Biotechnology·Xiaogang WangChenggang Zhang
Mar 20, 2009·Applied Microbiology and Biotechnology·Xiaogang WangChenggang Zhang
Feb 19, 2011·Cancer Immunology, Immunotherapy : CII·Mingkai XuChenggang Zhang
May 4, 2011·The FEBS Journal·Amanda J Brosnahan, Patrick M Schlievert
Oct 16, 2003·The Journal of Biological Chemistry·Anastassios C PapageorgiouK Ravi Acharya
Aug 2, 2000·Trends in Microbiology·A C Papageorgiou, K R Acharya
Oct 12, 2000·International Journal of Food Microbiology·N Balaban, A Rasooly

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