A structural basis for food allergy: the role of cross-reactivity

Current Opinion in Allergy and Clinical Immunology
Rana S BondsRandall M Goldblum

Abstract

Immunologic cross-reactivity, which is important in many aspects of host defense and immune-mediated diseases, is a prominent feature of allergic disorders. The goal of this article is to define allergenic cross-reactivity and its role in food allergy, review current understanding of mechanisms of cross-reactivity, and consider how advances in our ability to predict cross-reactivity can impact diagnosis and treatment of food allergy. Recent evidence suggests that specific T cells, in addition to IgE, developed in response to inhaled allergens can cross-react with related food allergens, leading to distinct clinical reactions. Several new cross-reactivities have been identified, including food-food, pollen-food, and latex-venom associations. Debate continues regarding prediction of allergenicity based on protein structure, and clinical relevance of in-vitro testing. Cross-reactivity is also being used to develop specific immunotherapy for treatment of food allergy. A thorough understanding of immunologic cross-reactivity is essential to advancing our knowledge about food allergy. This knowledge will help elucidate the pathogenesis of the disorder and prevent exposures to allergenic, genetically engineered foods. New insight will...Continue Reading

References

May 5, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·R Asero
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew B MellonKenneth C Fang
Apr 22, 2003·The Journal of Allergy and Clinical Immunology·Kay FoetischStefan Vieths
Jan 24, 2004·International Archives of Allergy and Immunology·Riccardo AseroStefano Amato
Feb 26, 2004·Allergy·F FerreiraA Mari
Apr 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kerstin WestritschnigRudolf Valenta
May 18, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S T H P BolhaarA C Knulst
Oct 28, 2004·Molecular Nutrition & Food Research·Kirsten Skamstrup HansenHans-Jørgen Malling
Jan 8, 2005·The Journal of Allergy and Clinical Immunology·John A JenkinsE N Clare Mills
May 3, 2005·Current Opinion in Allergy and Clinical Immunology·Adriano MariStefan Vieths
Jun 11, 2005·International Archives of Allergy and Immunology·Oussama AhrazemGabriel Salcedo
Sep 13, 2005·Clinical and Molecular Allergy : CMA·Mojtaba SankianMahmoud Mahmoudi
Oct 27, 2005·Journal of Agricultural and Food Chemistry·Catherine H ScheinWerner Braun
Feb 28, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H C FuchsH Breiteneder
May 3, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L ZuidmeerR van Ree
May 16, 2006·Immunological Investigations·Inmaculada Herrera-MozoCándido Juarez
Jun 6, 2006·The Journal of Allergy and Clinical Immunology·Aránzazu PalacínCarlos Blanco
Jul 4, 2006·The Journal of Allergy and Clinical Immunology·Barbara BohleChristof Ebner
Jul 15, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C RadauerH Breiteneder
Sep 5, 2006·The Journal of Allergy and Clinical Immunology·Rosa Sánchez-MongeGabriel Salcedo
Dec 29, 2006·International Archives of Allergy and Immunology·Riccardo AseroGianni Mistrello
Jan 18, 2007·International Archives of Allergy and Immunology·Emilia VassilopoulouNikolaos G Papadopoulos
Jan 26, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·I LauerS Scheurer
Feb 8, 2007·International Archives of Allergy and Immunology·R AlonsoA Cisteró-Bahíma
Feb 13, 2007·The Journal of Allergy and Clinical Immunology·Verena NiederbergerRudolf Valenta
Mar 6, 2007·The Journal of Allergy and Clinical Immunology·Justus AdédoyinMarianne van Hage
Mar 14, 2007·Biochimica Et Biophysica Acta·G SalcedoA Díaz-Perales
Mar 17, 2007·Allergy·P M GamboaM L Sanz
May 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ines SwobodaSusanne Spitzauer
May 17, 2007·International Archives of Allergy and Immunology·Riccardo AseroStefano Amato
Jul 11, 2007·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Denise G BukacelRami B Ibrahim

❮ Previous
Next ❯

Citations

May 29, 2009·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·R D RügerR Treudler
Sep 26, 2013·International Journal of Legal Medicine·Cristian PalmierePatrice Mangin
Mar 20, 2010·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Michael HauserMatthias Egger
Feb 10, 2016·Journal of Agricultural and Food Chemistry·Ángela María CandrevaSilvana Petruccelli
Jan 6, 2009·Regulatory Toxicology and Pharmacology : RTP·Ovidiu IvanciucWerner Braun
Oct 28, 2008·Molecular Immunology·Ovidiu IvanciucWerner Braun
May 13, 2008·The Journal of Allergy and Clinical Immunology·Stephan SteckelbroeckStefan Vieths
Nov 23, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Giovanni MelioliGiovanni Passalacqua
Nov 19, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A WangorschS Scheurer
Jul 19, 2012·Scandinavian Journal of Immunology·N E VinjeM Løvik
Oct 28, 2008·Molecular Immunology·Ovidiu IvanciucWerner Braun
Nov 30, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Eric AntignacHervé Toutain
Jan 13, 2012·The Journal of Allergy and Clinical Immunology·Benno WeigmannIris Bellinghausen
Feb 18, 2014·Acta Crystallographica. Section D, Biological Crystallography·Adela Rodríguez-RomeroSocorro Orozco-Martínez
Oct 29, 2010·Bioinformatics and Biology Insights·Catherine H ScheinWerner Braun
Apr 30, 2016·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Olivia E McKennaFatima Ferreira
Aug 13, 2017·Analytical and Bioanalytical Chemistry·Chung Y ChoEric A E Garber
Sep 11, 2013·Journal of Agricultural and Food Chemistry·Jaroslav GoliášLudmila Tučková
Jan 21, 2012·Journal of Agricultural and Food Chemistry·Joana CostaMaria Beatriz P P Oliveira
May 21, 2009·Current Opinion in Allergy and Clinical Immunology

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

© 2021 Meta ULC. All rights reserved