A structural equation modelling approach to explore the determinants of quality of life in schizophrenia

Schizophrenia Research
Marine AlessandriniLaurent Boyer

Abstract

This study aimed to analyse the relationships among psychotic symptoms, depression, neurocognition and functioning as determinants of quality of life (QoL) in patients with schizophrenia. In this cross-sectional study, we evaluated QoL with the Schizophrenia Quality of Life 18-item scale (S-QoL 18), neurocognition with multiple tests exploring memory, attention and executive functions, the severity of psychotic symptoms with the Positive and Negative Syndrome Scale (PANSS), depression with the Calgary Depression Scale for Schizophrenia (CDSS) and functioning using the Functional Remission Of General Schizophrenia (FROGS) scale. We used Structural Equation Modelling (SEM) to describe the relationships among the severity of psychotic symptoms, depression, neurocognition, functioning and QoL. Two hundred and seventy-one outpatients with schizophrenia participated in our study. SEM showed good fit with χ(2)/df=1.97, root mean square error of approximation=0.06, comparative fit index=0.93 and standardized root mean square residuals=0.05. This model revealed that depression was the most important feature associated with QoL, mainly for the self-esteem, autonomy and resilience dimensions (direct path coefficient=-0.46). The direct pat...Continue Reading

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Citations

May 5, 2017·Psychiatry and Clinical Neurosciences·Kazuyuki Nakagome
Mar 28, 2017·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Pierre MichelLaurent Boyer
Mar 15, 2018·Trends in psychiatry and psychotherapy·Lara Manuela Guedes de PinhoCláudia Margarida Correia Balula Chaves
Oct 11, 2017·European Psychiatry : the Journal of the Association of European Psychiatrists·A HoferH Uchida
Apr 12, 2020·Nutrients·Guillaume B FondLaurent Boyer
May 27, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Wei-Liang WangGuo-Hua Li
Mar 8, 2018·Geriatrics & Gerontology International·Chin Y CheongPhilip Lk Yap
Aug 15, 2018·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·David C BuitenwegChijs van Nieuwenhuizen
Jan 9, 2019·Frontiers in Psychiatry·Madeline W Z Lim, Jimmy Lee
Sep 19, 2020·Patient Preference and Adherence·Alejandra Caqueo-UrízarLaurent Boyer
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Feb 20, 2020·Journal of Clinical Psychology·Lara G PinhoCarme Ferré-Grau
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May 6, 2021·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Beatrice Frajo-AporAlex Hofer
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