A Structural Understanding of Class B GPCR Selectivity and Activation Revealed

Structure
Brian Krumm, Bryan L Roth

Abstract

Ma et al. (2020) and Liang et al. (2020) describe the cryo-EM structures of three class B G protein-coupled receptors (GPCRs) in complex with native peptides and Gs. Their work establishes the structural basis of peptide specificity and a conserved mechanism of receptor activation and G protein coupling for class B GPCRs.

References

Oct 29, 2009·The Journal of Biological Chemistry·Christina Rye UnderwoodSteffen Reedtz-Runge
Jul 19, 2013·Nature·Fai Yiu SiuRaymond C Stevens
Apr 25, 2017·Nature·Yi-Lynn LiangPatrick M Sexton
Jul 29, 2017·Cell·Daniel WackerBryan L Roth
Feb 8, 2019·Nature·Jiankun LyuJohn J Irwin
Jul 5, 2019·Nature Structural & Molecular Biology·Bryan L Roth
Feb 1, 2020·Molecular Cell·Yi-Lynn LiangDenise Wootten

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Citations

Jun 5, 2020·Cell Research·Chunyou MaoYan Zhang
Aug 9, 2020·The Journal of Biological Chemistry·Alexander VizurragaGregory G Tall
Jul 21, 2021·Biochemical Society Transactions·Matthew RosaGraham Ladds

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