A Structural View on Medicinal Chemistry Strategies against Drug Resistance

Angewandte Chemie
Stefano AgnelloRainer Riedl

Abstract

The natural phenomenon of drug resistance is a widespread issue that hampers the performance of drugs in many major clinical indications. Antibacterial and antifungal drugs are affected, as well as compounds for the treatment of cancer, viral infections, or parasitic diseases. Despite the very diverse set of biological targets and organisms involved in the development of drug resistance, the underlying molecular mechanisms have been identified to understand the emergence of resistance and to overcome this detrimental process. Detailed structural information on the root causes for drug resistance is nowadays frequently available, so next-generation drugs can be designed that are anticipated to suffer less from resistance. This knowledge-based approach is essential for fighting the inevitable occurrence of drug resistance.

References

Aug 1, 1978·The Journal of Infectious Diseases·D DixonT M Kerkering
Nov 11, 1976·Biochimica Et Biophysica Acta·R L Juliano, V Ling
Feb 1, 1992·AIDS Research and Human Retroviruses·C Debouck
Apr 20, 1990·Science·N A RobertsA Kröhn
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P A FurmanH Mitsuya
Mar 1, 1988·Journal of Medicinal Chemistry·A BrossiW Peters
Apr 1, 1986·Annals of Tropical Medicine and Parasitology·G E Childs, C Lambros
Sep 1, 1969·Journal of Medicinal Chemistry·E F GodefroiP A Janssen
Jul 1, 1984·Antimicrobial Agents and Chemotherapy·A Espinel-IngroffR J Gebhart
Apr 1, 1984·Molecular and Biochemical Parasitology·C E GarrettD V Santi
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·S J SmerdonT A Steitz
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·D W RodgersS C Harrison
Apr 1, 1995·Nature Structural Biology·J RenD Stuart
May 1, 1993·Antimicrobial Agents and Chemotherapy·T J DuewekeL Resnick
Sep 1, 1994·Bioorganic & Medicinal Chemistry·D J KempfN E Wideburg
Apr 1, 1995·Nature Structural Biology·L K NicholsonP K Jadhav
Feb 17, 1995·Journal of Medicinal Chemistry·M L VazquezG P Kocan
Nov 1, 1994·Transactions of the Royal Society of Tropical Medicine and Hygiene·K HarukiG Y Ritchie
Aug 1, 1994·Antimicrobial Agents and Chemotherapy·W AsawamahasakdaS R Meshnick
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·J P VaccaE Roth

❮ Previous
Next ❯

Citations

May 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roberto RomeoSalvatore V Giofrè
Jun 11, 2019·Expert Opinion on Drug Discovery·Thomas FischerRainer Riedl
Jan 21, 2020·Organic & Biomolecular Chemistry·Laure Peilleron, Kevin Cariou
Jul 23, 2020·Molecular Microbiology·Arianne Bermas, Jennifer Geddes-McAlister
Oct 31, 2019·Nucleic Acids Research·Xinyi LiuJian Zhang
Apr 26, 2019·Organic & Biomolecular Chemistry·Paula López RivasCesare Gennari
Dec 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Silvia PanzeriUmberto Piarulli
Apr 20, 2021·Journal of Biomolecular Structure & Dynamics·Prem Prakash SharmaBrijesh Rathi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Virginia Medical Monthly
C C COLEMAN, J M HUTCHESON
Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum
W Schneider
Svensk farmaceutisk tidskrift
R Westerling
L' Infirmière canadienne
M Mair
© 2022 Meta ULC. All rights reserved