A structure-activity relationship for the neurotoxicity of triazole fungicides

Toxicology Letters
K M Crofton

Abstract

Previous work has demonstrated that acute exposures to the triazole fungicide triadimefon affects central nervous system (CNS) catecholamines and induces a transient syndrome in rats that consists of hyperactivity and stereotyped behaviors. The present research was designed to determine whether this type of CNS toxicity is characteristic of other triazoles. Dose-effect functions were determined for 14 different triazoles or structurally related pesticides in adult male Long-Evans rats. All chemicals were administered per os in corn oil. Hyperactivity was measured for 2 h in figure-eight mazes. Results indicated that only triadimefon and triadimenol were able to induce hyperactivity; none of the other chemicals produced this effect. These data suggest a very rigid structure-activity relationship (SAR) for the hyperactivity syndrome and indicate that CNS effects may be minimized in the future design of triazoles without impacting fungicidal efficacy.

References

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Citations

May 28, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Harm J HeusinkveldRemco H S Westerink
Jul 6, 2014·Neurotoxicology·Pablo ValdiviaTimothy J Shafer
Mar 12, 2013·Environmental Toxicology and Pharmacology·Minling GaoJing Guo
Mar 27, 2016·Archives of Toxicology·Marilena ColaiannaKarl-Heinz Krause
Feb 24, 2006·Biochemical Pharmacology·Richard L Monaghan, John F Barrett
Dec 23, 2009·Toxicology Letters·Susan R CrowellJohn F Kenneke
Jun 28, 2016·Critical Reviews in Toxicology·Katie Paul FriedmanRichard C Peffer
Aug 3, 2016·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Chuyan CaoGuonian Zhu
Sep 27, 2016·Environmental Pollution·Viera SchwarzbacherováJán Dianovský
Jan 16, 2015·International Journal of Toxicology·Lee C B CrouseGlenn J Leach
Aug 11, 2017·Journal of Clinical Pharmacy and Therapeutics·Y BennisK Masmoudi
Mar 30, 2018·Mikrochimica Acta·Mir Mahdi AbolghasemiMarzieh Piryaei
Jan 1, 2020·Environmental Science and Pollution Research International·Zikang WangZhiqiang Zhou
Feb 16, 2021·Expert Opinion on Drug Metabolism & Toxicology·Emma E J Kasteel, Remco H S Westerink
Apr 12, 2021·Pesticide Biochemistry and Physiology·Yosra Ben OthmèneSalwa Abid-Essefi
Jun 13, 2018·Pesticide Biochemistry and Physiology·Hiba HamdiSalwa Abid-Essefi

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