A structure-function analysis of the left ventricle

Journal of Applied Physiology
Edward P SnellingShane K Maloney

Abstract

This study presents a structure-function analysis of the mammalian left ventricle and examines the performance of the cardiac capillary network, mitochondria, and myofibrils at rest and during simulated heavy exercise. Left ventricular external mechanical work rate was calculated from cardiac output and systemic mean arterial blood pressure in resting sheep (Ovis aries; n = 4) and goats (Capra hircus; n = 4) under mild sedation, followed by perfusion-fixation of the left ventricle and quantification of the cardiac capillary-tissue geometry and cardiomyocyte ultrastructure. The investigation was then extended to heavy exercise by increasing cardiac work according to published hemodynamics of sheep and goats performing sustained treadmill exercise. Left ventricular work rate averaged 0.017 W/cm3 of tissue at rest and was estimated to increase to ∼0.060 W/cm3 during heavy exercise. According to an oxygen transport model we applied to the left ventricular tissue, we predicted that oxygen consumption increases from 195 nmol O2·s-1·cm-3 of tissue at rest to ∼600 nmol O2·s-1·cm-3 during heavy exercise, which is within 90% of the oxygen demand rate and consistent with work remaining predominantly aerobic. Mitochondria represent 21-22% ...Continue Reading

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Citations

Jul 13, 2018·The Journal of Experimental Biology·Edward P SnellingRoger S Seymour
Apr 18, 2019·Journal of Anatomy·Edward P SnellingTilaye Wube
Sep 21, 2018·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Adian IzwanShane K Maloney
May 9, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ali AhmadiLisa M Mielniczuk

Related Concepts

Metazoa
Diastolic Blood Pressure
Cardiac Output
In Silico
Goat
Left Ventricular Structure
Mitochondria, Heart
Models, Anatomic
Dioxygen
Oxygen Consumption

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