A structure prediction for the ligand-binding region of the integrin beta subunit: evidence for the presence of a von Willebrand factor A domain

FEBS Letters
D S Tuckwell, M J Humphries

Abstract

The integrins are a family of cell surface receptors that mediate biologically important adhesive interactions. Integrin-ligand binding has been extensively studied because of the potential for the development of anti-adhesive therapies, but the molecular basis of this interaction is still poorly understood. A conserved region near the N-terminus of the beta subunit appears to be of particular importance in ligand binding, but to date this domain has not been expressed in isolation. As a prelude to expression and potential structure determination, we have performed a detailed structure prediction for this region. Primary, secondary and tertiary structure analyses indicate that the region folds into a von Willebrand factor A-domain, thereby potentially placing a previously characterised module at the centre of a key functional region.

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Citations

Jan 17, 2002·International Journal of Hematology·T Kamata, Y Takada
Jan 19, 2000·Trends in Pharmacological Sciences·M J Humphries
May 14, 1999·Immunology Today·M E Binnerts, Y van Kooyk
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Dec 31, 2002·Current Opinion in Structural Biology·Timothy A Springer
Jul 3, 1999·Trends in Biochemical Sciences·P BorkB Snel
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Jun 22, 2006·BMC Cell Biology·A Paul MouldMartin J Humphries
Oct 28, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John M ProctorLouis F Reichardt
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·J M CasasnovasT A Springer
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·C OxvigT A Springer
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May 10, 2008·The Journal of Comparative Neurology·Jun-Ping CaoDian-Shuai Gao
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Mar 16, 2004·The Journal of Biological Chemistry·Anne StefanssonStaffan Johansson

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