PMID: 9438527Jan 23, 1998Paper

A study examining intravenous ethanol-conditioned place preference in C57BL/6J mice

Alcoholism, Clinical and Experimental Research
B M KelleyL D Middaugh

Abstract

The reinforcing effects of intravenous (I.V.) ethanol were examined in C57BL/6J (C57) mice with a conditioned-place-preference (CPP) paradigm. Before CPP testing, adult mice underwent jugular catheterization. On the following day, subjects were acclimated to a two-compartment CPP chamber. A 15-min nondrug pretest was conducted to determine compartment preference. For the treatment group, I.V. ethanol [30% (v/v), 3.4 microl/min, 25 min] was paired with the nonpreferred compartment, whereas I.V. saline was paired with the preferred compartment. The control group received I.V. saline in both compartments. Two conditioning sessions were conducted per day (0900 and 1500), and the order of the infusions was counterbalanced across subjects. The drug-free posttest was identical to the pretest, except that it occurred on the day after the final drug/compartment pairing. The entire procedure required 6 days. After just two pairings with ethanol, with a cumulative ethanol dose of only 0.82 g/kg/day, significant CPP was noted in the treatment group, whereas no change in compartment preference was noted for the control group. A separate group of C57 mice were trained to discriminate intraperitoneal ethanol (1.5 g/kg) from saline using a two...Continue Reading

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Citations

Aug 31, 2001·Pharmacology, Biochemistry, and Behavior·N J GrahameL Lumeng
Aug 15, 2002·Pharmacology, Biochemistry, and Behavior·Christopher L CunninghamTara L Fidler
Jan 19, 2000·Pharmacology, Biochemistry, and Behavior·L D MiddaughE R Cuison
Jun 12, 2002·Alcohol·Julia A Chester, Christopher L Cunningham
Mar 19, 2014·Pharmacology, Biochemistry, and Behavior·Christian BrabantEtienne Quertemont
Feb 6, 2007·Brain Research·William C GriffinHoward C Becker
May 20, 2014·Alcohol·Kyle A WindischCristine L Czachowski
Sep 24, 2004·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Brian M Kelley, James D Rowan
Apr 9, 1999·Alcoholism, Clinical and Experimental Research·L D MiddaughC H Groseclose
Apr 1, 2006·Alcoholism, Clinical and Experimental Research·Jennifer Lynn ShortAndrew John Lawrence
Sep 1, 2000·Alcoholism, Clinical and Experimental Research·L D MiddaughA L Bandy
Apr 20, 2002·Alcoholism, Clinical and Experimental Research·W J McBrideA Noronha

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