A study of accessory cells in the acquired lymphoid tissue of helicobacter gastritis

The Journal of Pathology
P SarsfieldD H Wright

Abstract

This paper presents a description of the patterns of distribution of accessory cells in helicobacter gastritis and low-grade gastric MALT lymphomas. The use of gastric resection specimens afforded abundant, well-orientated lymphoid tissue. Fifteen cases were selected from patients with MALT lymphomas, three with gastritis alone, and six histologically normal controls. A panel of antibodies working in paraffin-embedded tissue, identifying differing accessory cells, was used. These comprised antibodies to HLA class II (WR18), acid cysteine proteinase inhibitor (ACPI), CD68 (PGM1), Factor XIIIa, S100 protein, CD23 (BU38), CD106 (V-CAM1), CD55 (BRIC 128), and CD21 (1F8). CD68-positive macrophages in the gastritis cases were abundant in the superficial mucosa. Factor XIIIa also identified dendritic cells at deeper sites but these were absent from both the acquired and the neoplastic lymphoid tissue. Antibodies to both S100 protein and ACPI stained dendritic cells localized to areas within and adjacent to the lymphoid tissue only. S100 protein-positive cells were concentrated in close contact with glandular epithelium immediately above the germinal centres, while ACPI-positive dendritic cells were identified, especially around the mo...Continue Reading

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Citations

Mar 20, 2010·Mucosal Immunology·D BimczokL E Smythies
Apr 20, 2007·FEMS Immunology and Medical Microbiology·Ann-Mari Svennerholm, Anna Lundgren
Sep 2, 2015·The Korean Journal of Parasitology·Denise Patricia Mawili-MboumbaMarielle Karine Bouyou-Akotet
Nov 27, 2010·Expert Review of Gastroenterology & Hepatology·Malin Sundquist, Marianne Quiding-Järbrink
Jul 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Frank Serge LehmannChristoph Beglinger
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nadia HafsiChristian Prinz
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Victor J TorresTimothy L Cover
Feb 14, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·John Y KaoJuanita L Merchant

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