A study of anti-inflammatory activity of some novel alpha-amino naphthalene and beta-amino naphthalene derivatives

Archiv der Pharmazie
Shalabh SharmaAshok Kumar

Abstract

In the present study, some naphthalene derivatives have been synthesized by incorporating azetidinyl and thiazolidinyl moieties at its alpha- or beta-positions such as alpha-(3-chloro-2-oxo-4-substituted)aryl-1-azetidinyl)naphthalenes 6-10, alpha-((substituted)aryl-4-oxo-1,3-thiazolidin-3-yl)naphthalenes 11-15, beta-(3-chloro-2-oxo-4-substituted aryl-1-azetidinyl)naphthalenes 21-25, and beta-(substituted aryl-4-oxo-1,3-thiazolidin-3-yl)naphthalenes 26-30. These compounds have also been screened for acute toxicity and anti-inflammatory and analgesic activities. Compounds which showed better anti-inflammatory and analgesic activities were also examined for their ulcerogenic liability and underwent a cyclooxygenase assay. Two compounds, 12 and 28, were found to exhibit potent anti-inflammatory activity as compared to the standard drugs phenylbutazone and naproxen.

References

Dec 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·C A WINTERG W NUSS

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Citations

Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Patrícia D NeuenfeldtSolange M S V Wardell
Jan 6, 2012·Acta Crystallographica. Section E, Structure Reports Online·Victor FacchinettiEdward R T Tiekink
Oct 31, 2012·Molecular Diversity·Sergey V RyabukhinAlexander N Shivanyuk
Dec 3, 2014·European Journal of Medicinal Chemistry·Ibrahim ChaabanVânia M Moreira
Jan 1, 2014·International Scholarly Research Notices·Piyush B VekariyaHitendra S Joshi
Dec 3, 2020·European Journal of Medicinal Chemistry·Lan LuoLing He

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