A study of atypical APTT derivative curves on the ACL TOP coagulation analyser

International Journal of Laboratory Hematology
C SolanoR Bird

Abstract

The graphical representation of clotting data can provide useful information. A novel feature of the ACL TOP software allows display of clot reaction curves with superimposed first and second derivative curves. We noted atypical derivative plots associated with normal 'S'-shaped clot reaction curves in some abnormal activated partial thromboplastin time (APTT). We tested 179 citrate plasmas with four different APTT reagents on the ACL TOP. We documented the prevalence and utility of these APTT atypical derivative curves in these patients. Ellagic acid APTT reagents commonly produce atypical derivative curves despite normal 'S'-shaped clot reaction curves. Occasionally, these atypical second derivative curves may cause incorrect APTT results. With silica activator APTT reagents, atypical derivative curves were associated with genuine coagulation abnormalities such as single factor deficiencies and lupus anticoagulants (LAs). To our knowledge, this novel finding has not been reported. Atypical derivative curves seen in ellagic acid APTTs are of limited diagnostic use because of the frequency with which they occur. This may be related to the need to optimize the data reduction utilized on the ACL TOP for these reagents. With silic...Continue Reading

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Citations

Apr 20, 2017·International Journal of Laboratory Hematology·M F RubertoF Marongiu
Dec 8, 2017·International Journal of Laboratory Hematology·M F RubertoD Barcellona
Feb 15, 2018·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Haruna KatayamaNaoyuki Katayama
Sep 9, 2017·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Takeshi MatsumotoNaoyuki Katayama
Oct 17, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Maria Filomena RubertoDoris Barcellona
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Nov 17, 2020·Frontiers in Immunology·Tatiana KoudriavtsevaMatilde Inglese
Mar 6, 2021·Scientific Reports·Takuya ShimuraYutaka Yatomi

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