A study of capecitabine metronomic chemotherapy is non-inferior to conventional chemotherapy as maintenance strategy in responders after induction therapy in metastatic colorectal cancer

Trials
Min ShiJun Zhang

Abstract

The aim of this study is to demonstrate that capecitabine metronomic chemotherapy is non-inferior to capecitabine conventional chemotherapy as maintenance treatment, in patients who have responded to 16-18 weeks first-line chemotherapy in metastatic colorectal cancer (mCRC). The study design is a prospective, randomized, open label, phase II clinical trial. Those patients with mCRC who respond well after 16-18 weeks of standard doublet chemotherapy as induction may be enrolled into this study, and randomly assigned to the capecitabine metronomic group or standard dosage group. The duration of disease control after randomization and progression-free survival after enrollment are the primary endpoints. Overall survival, safety, and quality of life are the secondary endpoints. The sample size required to achieve the research objectives of this project is 79 patients in each group. The study recently started on 1 January 2018, and will last for 36 months. This project is intended to study the efficacy and safety of capecitabine metronomic chemotherapy in the maintenance treatment of advanced colorectal cancer, and to explore the strategy of "low toxicity, high efficiency, economy, and individualization", which is suitable for China...Continue Reading

References

May 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S D WeitmanB A Kamen
Aug 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A de GramontA Bonetti
Aug 7, 2003·Seminars in Radiation Oncology·Andy TrottiPhilip Rubin
Dec 11, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard M GoldbergSteven R Alberts
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
Jan 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christophe TournigandAimery de Gramont
Apr 3, 2009·The New England Journal of Medicine·Eric Van CutsemPhilippe Rougier
Jul 14, 2009·Journal of Translational Medicine·Ramon KanenoMichael R Shurin
Jan 14, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C BokemeyerP Koralewski
Apr 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric Van CutsemFortunato Ciardiello
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Apr 11, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J Y DouillardR Sidhu
Jul 25, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S R BerryUNKNOWN Cancer Care Ontario's Gastrointestinal Disease Site Group
Jun 5, 2015·Gut·Eline H SchreudersErnst J Kuipers
Mar 2, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jul 29, 2018·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E ArandaUNKNOWN Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
Feb 9, 2019·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Chiara CremoliniAlfredo Falcone
Jul 1, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J Y DouillardR Sidhu

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Citations

Dec 1, 2020·Critical Reviews in Oncology/hematology·Palma FedeleSaverio Cinieri

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Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS

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