PMID: 7542422Jan 1, 1995Paper

A study of dementia with argyrophilic grains. Possible cytoskeletal abnormality in dendrospinal portion of neurons and oligodendroglia

Acta Neuropathologica
K IkedaC Haga

Abstract

Two mildly demented patients with emotional disorder presented massive cortical argyrophilic grains (ArG) in the limbic area and coiled bodies mainly in the white matter. Immunohistochemically, the ArG consisted of partially ubiquitinated full-length phosphorylated tau. A modified Gallyas-Braak method, used after potassium permanganate and oxalic acid pretreatment, revealed many filiform, knobby or pleomorphic spine-like appendages on the ArG. Double immunohistochemical staining using anti-tau with either anti-microtubule-associated protein 2 or anti-neurofilament 200K revealed that ArG were intimately associated with dendrites rather than with axons. Electron microscopic studies with tau immunohistochemistry and the Gallyas-Braak method revealed that the ArG were composed of bundles of smooth tubules of 25-nm diameter. The coiled body-bearing cells had the morphological characteristic of oligodendroglia. These results indicate that the presence of ArG is a cytoskeletal abnormality affecting predominantly the dendrospinal portions of neurons. A survey of diseases with cytoskeletal disorders revealed that a small number of similar argyrophilic granular structures are sometimes observed in progressive supranuclear palsy, Pick's d...Continue Reading

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Citations

Mar 10, 2006·Acta Neuropathologica·Zheng-Tong DingYoshio Hashizume
Apr 18, 2002·Journal of the Neurological Sciences·Yuko SaitoShigeo Murayama
Feb 1, 2008·Brain : a Journal of Neurology·Isidro FerrerFred W van Leeuwen
Apr 18, 2000·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·D G Munoz
Jun 17, 2015·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Taku HommaTakashi Komori
Jun 11, 2010·Journal of Neuropathology and Experimental Neurology·Tadashi AdachiShigeo Murayama
Jun 20, 2006·Journal of Neuropathology and Experimental Neurology·Gregory A JichaJoseph E Parisi
Oct 24, 1998·Experimental Neurology·H Braak, E Braak
Jul 28, 2013·The American Journal of Pathology·David J IrwinJohn Q Trojanowski
Nov 1, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A IshikiK Furukawa
Dec 18, 2013·Journal of Neuropathology and Experimental Neurology·Shinsui TatsumiMari Yoshida
Jan 1, 2013·Journal of Experimental Neuroscience·Alberto RábanoJesús Avila
Oct 26, 2018·Annual Review of Pathology·Jürgen GötzRebecca M Nisbet
Jul 27, 1999·Pathology International·T KawashimaT Iwaki
Jan 1, 2009·Dementia & Neuropsychologia·Lea T Grinberg, Helmut Heinsen
Apr 5, 2005·Journal of Neuropathology and Experimental Neurology·Yasuhiro FujinoDennis W Dickson
Jan 1, 2015·Dementia & Neuropsychologia·Roberta Diehl Rodriguez, Lea Tenenholz Grinberg
Apr 18, 1998·Brain Pathology·K A Jellinger
Nov 19, 2020·Brain Sciences·Antonio Dominguez-MeijideTiago Fleming Outeiro
Jul 17, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Nobuyuki OkamuraYukitsuka Kudo

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