A study of DNA melting in concentrated water-alcohol solutions

Journal of Biomolecular Structure & Dynamics
I A Mikhailenko, L S Shlyakhtenko

Abstract

The DNA melting profiles with high resolution have been studied for conditions corresponding to the B and A conformations of DNA in water-alcohol solutions. The melting profiles of the A-form and B-form DNA, their mean melting temperatures and melting range width were found to differ. DNA was shown to be heterogeneous in respect of the B-A transition, the GC-rich regions more readily converting into the A form than AT-rich ones. The presence of boundaries between the A and B sections within the transition zone did not smooth off the fine structure of melting profiles.

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Citations

Jan 1, 1986·Progress in Biophysics and Molecular Biology·A Wada, A Suyama
Mar 12, 2009·Journal of the American Chemical Society·Thorsten NeumannLuc Jaeger
Jun 1, 1984·Journal of Biomolecular Structure & Dynamics·L S Shlyakhtenko
Feb 18, 2006·The Journal of Chemical Physics·William K Lewis, Roger E Miller
Aug 1, 1985·Journal of Biomolecular Structure & Dynamics·V I IvanovE E Minyat

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