A study of drug-resistant childhood epilepsy testing the new ILAE criteria

Seizure : the Journal of the British Epilepsy Association
J Ramos-LizanaE Cassinello-García

Abstract

To test the new ILAE definition of drug-resistant epilepsy in a cohort study. All children younger than 14 with two or more unprovoked seizures observed at our hospital between 1994 and 2008 were included. Five hundred and eight patients were followed for an average of 90 months (range 24-168). The probabilities of achieving seizure freedom, according to the ILAE criteria, with the first, second, third and fourth and subsequent therapeutic regimens were 65%, 29%, 27% and 21%, respectively. In the cohort, 87 patients met the criteria for drug-resistant epilepsy, which represents 19% of the treated patients (n=459) and 17% of the overall sample. The probability of meeting the criteria for drug-resistant epilepsy was 11%, 11% and 13% at 2, 6 and 10 years respectively. Sixty two percent of drug resistant cases were younger than 4 years old, 73% had an associated developmental delay and/or motor deficit, 42% had an identifiable structural cause of epilepsy and 32% had a specific epileptic syndrome. For drug-resistant patients who tried additional therapeutic regimens, the probability of achieving a seizure-free state without further recurrences was 23% and 27% at three and five years, respectively. Compared with more stringent crite...Continue Reading

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Aug 7, 2009·Seizure : the Journal of the British Epilepsy Association·J Ramos-LizanaE Cassinello-García

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Citations

Sep 4, 2013·Epilepsy & Behavior : E&B·Vicente VillanuevaMontserrat Asensio
Jan 6, 2016·Epilepsy & Behavior : E&B·Giorgia GiussaniUNKNOWN EPIRES Group
Jan 29, 2016·Journal of Epilepsy Research·Pairoj BoonluksiriKamornwan Katanyuwong
Jun 24, 2015·Epilepsy & Behavior Case Reports·Brahyan Galindo-MendezCarlos Calderon-Ospina
Dec 15, 2015·Fundamental & Clinical Pharmacology·Ricardo V SoaresStéphanie Chhun
Sep 1, 2015·Revue neurologique·S FrayS Belal
Jun 14, 2016·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·Laura Ochoa-GómezMaría Concepción García-Jiménez
Nov 28, 2016·European Journal of Clinical Pharmacology·Daria PutignanoMaurizio Bonati
Sep 4, 2018·Neurosurgical Focus·Erin N KiehnaRobert J Bollo
Feb 24, 2021·Disease Models & Mechanisms·Grant F MarshallCatherine M Abbott

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