A study of dysphagia symptoms and esophageal body function in children undergoing anti-reflux surgery

United European Gastroenterology Journal
Taher OmariDavid Moore

Abstract

The role of high-resolution esophageal impedance manometry (HRIM) for establishing risk for dysphagia after anti-reflux surgery is unclear. We conducted a prospective study of children with primary gastroesophageal reflux (GER) disease, for whom symptoms of dysphagia were determined pre-operatively and then post-operatively and we examined for features that may predict post-operative dysphagia. Thirteen children (aged 6.8-15.5 years) undergoing work-up prior to 360o Nissen fundoplication were included in the study. A dysphagia score assessed symptoms at pre-operative study and post-operatively (mean 1.4 years). A HRIM procedure recorded 5-ml liquid, 5-ml viscous and 2-cm solid boluses. We assessed esophageal motility, esophago-gastric junction (EGJ) morphology, EGJ contractility and pressure-flow variables indicative of bolus distension pressures and bolus clearance pressures. A composite pressure-flow index score was also derived. Pre-operative pressure-flow index was positively correlated with post-operative dysphagia score (viscous bolus r = 0.771, p < 0.005). Of three variables that comprise the pressure-flow index, the ramp pressure measured during bolus clearance was the main driver of the effect seen (viscous bolus r = 0...Continue Reading

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Citations

Aug 7, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ravinder K MittalAli Zifan
Apr 18, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Maissa RayyanNathalie Rommel
Mar 20, 2019·Journal of Pediatric Gastroenterology and Nutrition·Maissa RayyanNathalie Rommel
Jun 20, 2020·Annals of the New York Academy of Sciences·Peter I WuHans Gregersen
Sep 16, 2020·Journal of Pediatric Gastroenterology and Nutrition·Jonathan E M O'DonnellUsha Krishnan
Nov 17, 2020·Journal of Paediatrics and Child Health·Taher I Omari, Usha Krishnan

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Methods Mentioned

BETA
biopsy
rheology

Software Mentioned

AIMplot
HRIM
MATLAB

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