A study of empyema thoracis and role of intrapleural streptokinase in its management

BMC Infectious Diseases
Amit BangaNamrata Banga

Abstract

Clinical spectrum, microbiology and outcome of empyema thoracis are changing. Intrapleural instillation of fibrinolytic agents is being increasingly used for management of empyema thoracis. The present study was carried out to describe the clinical profile and outcome of patients with empyema thoracis including those with chronic empyema and to study the efficacy and safety of intrapleural streptokinase in its management. Clinical profile, etiological agents, hospital course and outcome of 31 patients (mean age 40 +/- 16 years, M: F 25: 6) with empyema thoracis treated from 1998 to 2003 was analyzed. All patients were diagnosed on the basis of aspiration of frank pus from pleural cavity. Clinical profile, response to therapy and outcome were compared between the patients who received intrapleural streptokinase (n = 12) and those who did not (n = 19). Etiology was tubercular in 42% of the patients (n = 13) whereas the rest were bacterial. Amongst the patients in which organisms could be isolated (n = 13, 42%) Staphylococcus aureus was the commonest (n = 5). Intrapleural streptokinase was instilled in 12 patients. This procedure resulted in increase of drainage of pleural fluid in all patients. Mean daily pleural fluid drainage a...Continue Reading

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Citations

Aug 31, 2007·Journal of the American Geriatrics Society·Ali A El SolhLilibeth A Pineda
Jun 30, 2019·The European Respiratory Journal·Maged HassanNajib M Rahman
Aug 9, 2019·The European Respiratory Journal·Tamsin N CargillNajib M Rahman
Oct 20, 2019·Indian Journal of Pediatrics·Devki NandanSandhya Lata
Jan 1, 2019·Indian Journal of Thoracic and Cardiovascular Surgery : Official Organ, Association of Thoracic and Cardiovascular Surgeons of India·Sanjeev KumarArshad Ahmad

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