A study of erythrocyte membrane cation transport adenosine triphosphatases in pregnancy-induced hypertension and of in vivo effects of diuretic treatment

Clinica Chimica Acta; International Journal of Clinical Chemistry
S S Kaplay, K Prema

Abstract

Plasma and erythrocyte Na+ and K+ and erythrocyte membrane (EM) Na+, K+ ATPase, Mg2+ ATPase and Ca2+, Mg2+ Atpase activities were studied in four groups of women -- non-pregnant, normal pregnant, with pregnancy edema (PE) and with pregnancy induced hypertension (PIH). The effect of diuretic therapy in PE and PIH was also evaluated. Plasma Na+ concentration was higher in PE and PIH. There was a significant reduction in (Na+ + K+) ratio between cell and plasma in these two groups. EM Na+, K+ ATPase was unaltered in PE and PIH. The Mg2+ ATPase was elevated by 44% in PE and by 100% in PIH subjects. There was a 50% reduction in Ca2+, Mg2+ ATPase activity in PE. Diuretic therapy had no effect either on electrolyte levels or on any of the EM ATPases. From these results it may be concluded that Na, K, ATPase -- which in kidney is a site of action for furosemide, a potent diuretic -- is unaffected in PE and PIH and, hence, treatment with diuretics -- is unaffected in PE and PIH and, hence, treatment with diuretics in such patients may be ineffective.

References

Aug 15, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·S S Kaplay, M Ramanadham
Sep 7, 1978·The New England Journal of Medicine·M W LoesB L Mirkin
Sep 30, 1976·Pflügers Archiv : European journal of physiology·Y U PostnovA Shevchenko
Oct 1, 1972·The Journal of Obstetrics and Gynaecology of the British Commonwealth·E W Page
Apr 26, 1973·The New England Journal of Medicine·M D Lindheimer, A I Katz
Oct 1, 1973·American Family Physician·A R RemmersH E Sarles
Feb 1, 1974·Scandinavian Journal of Clinical and Laboratory Investigation·J Astrup

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Citations

Apr 1, 1984·Biulleten' eksperimental'noĭ biologii i meditsiny·V D Prokop'evaN P Larionov
Jul 31, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·J Rubython, D B Morgan
Jan 23, 2009·Journal of Perinatology : Official Journal of the California Perinatal Association·C D AdairV Buckalew

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