PMID: 9663515Jul 15, 1998Paper

A study of familial aggregation of depression, dementia and Parkinson's disease

European Journal of Epidemiology
S FahimA Hofman

Abstract

Depression is often accompanied by other disorders including Alzheimer's disease and Parkinson's disease. We studied the familial aggregation of these disorders in order to examine the possibility of a shared genetic origin. In a population-based study of 6596 subjects, we studied the association of self-reported depression, which required treatment by a psychiatrist, to family history of psychiatric disease, dementia, and Parkinson's disease. A family history of psychiatric disease was significantly associated with overall depression as well as with unipolar (n = 303 patients) and bipolar (n = 27 patients) depression. The risk of unipolar depression was associated with the presence of two or more demented individuals among their first degree relatives (e.g. parents, siblings and children). Since there was no evidence for familial aggregation in subjects with only one demented relative, our study suggests that unipolar depression may be associated specifically to a strongly familial, form of dementia. The risk of bipolar depression was increased for those with one or more relatives with dementia and, perhaps, for those with relatives with Parkinson's disease. The familial aggregation of depression with dementia and perhaps Park...Continue Reading

Citations

Aug 2, 2006·Journal of Geriatric Psychiatry and Neurology·Dilip V JesteGeorge S Zubenko
Jan 6, 2011·International Psychogeriatrics·Janardhanan C NarayanaswamyThennarasu Kandavel
Sep 29, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·J A Saint-Cyr, L L Trépanier
Jul 27, 2000·Journal of Geriatric Psychiatry and Neurology·D G HarwoodR Duara
Feb 26, 2005·Annals of Neurology·Gloria Dal FornoClaudia H Kawas
Oct 17, 2002·European Psychiatry : the Journal of the Association of European Psychiatrists·Reinhard HeunUrsula Ptok
Jun 3, 2011·European Journal of Epidemiology·Karin WirdefeldtJack Mandel
Apr 15, 2003·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Jean A Saint-Cyr
Nov 12, 2009·Expert Review of Neurotherapeutics·Norifumi Tsuno, Akira Homma
Jun 25, 2010·Psychiatry and Clinical Neurosciences·Christian Even, Daniel Weintraub

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