PMID: 45355Jan 1, 1979

A study of gamma-glutamyl-transpeptidase and of the ratio of IgA to transferrin in the pregnant woman (and when using oral contraception) and in the newborn (author's transl)

Journal de gynécologie, obstétrique et biologie de la reproduction
G CrépinD Bonte-Lecomte


The authors confirm the absence of a marked variation in levels of gamma-glutamyl-transpeptidase in women under the influence of oestrogens, but a considerable rise in this enzyme in the newborn, particularly after delivery following vaginal obstetrical manoeuvre. They base these findings on 242 samples taken from pregnant women in the 3 trimesters of normal pregnancies and after delivery, and in the cord blood of newborn infants as well as in patients taking oral contraception. There is a slight rise in the levels of immunoglobulins A in the 3rd trimester of pregnancy. The overall rise in the blood levels of transferrin under the effect of oestrogens is confirmed. Norms were obtained for the levels of the IgA/T ratio which drops progressively as pregnancy progresses and with oral contraception. It has been found that in the last two trimesters the upper limit of the normal is 1 for the IgA/T ratio as compared with 1.9 in the general population. The study of these constants is of value when screening for maternal alcoholism and as a consequence for the prevention of the fetal alcohol syndrome.

Related Concepts

Gamma-glutamyl transferase
Transferrin C
Pregnancy Trimester, Third
Oral Contraceptives, Phasic

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