PMID: 9450244Feb 5, 1998Paper

A study of granulated metrial gland cells in the pregnant, alymphoplasia (aly/aly) mice

The Journal of Veterinary Medical Science
Y KisoF Sasaki

Abstract

During pregnancy, a population of uterine NK cells, commonly called granulated metrial gland (GMG) cells, differentiates in the uterus of both immune competent and various immunodeficient mice. Regulatory mechanisms controlling the differentiation of GMG cells are not fully known. It has been proven that GMG cells are derived from bone marrow, appear under the influences of progesterone and estrogen, do not require the presence of an embryo, and are associated in rodents with decidualization of the uterine stroma. Mice of genotype aly/aly are genetically deficient in lymph nodes and Peyer's patches due to a lymphoid-associated mesenchymal disorder. They are considered to be a useful model for the study of interactions between lymphocytes and stromal components. This immunodeficient animal is completely different from nu/nu and scid/scid mice who differentiate GMG cells during pregnancy. To determine whether the differentiation of GMG cells depends on mesenchymal interactions in the uterus, aly/aly mice were studied histologically between days 10 and 14 of pregnancy for differentiation of GMG cells and development of the metrial gland. Metrial gland tissue was present and appeared normal in aly/aly mice. There were no significan...Continue Reading

References

Jan 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L M ZhengJ D Young
Jul 1, 1989·Journal of Reproductive Immunology·D D MukhtarB A Croy
Apr 1, 1994·The Journal of Veterinary Medical Science·M YoshizawaY Kiso
Apr 1, 1993·Journal of Reproductive Immunology·B A CroyY Kiso
Jun 15, 1993·Microscopy Research and Technique·B A Croy, Y Kiso
Jun 1, 1996·American Journal of Reproductive Immunology : AJRI·M J GuimondB A Croy

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Citations

Jul 1, 2004·The Journal of Reproduction and Development·Orie NakamuraYasuo Kiso
Nov 24, 1999·The Journal of Veterinary Medical Science·K KusakabeY Kiso
Nov 15, 2006·Immunological Reviews·B Anne CroyChandrakant Tayade
Mar 6, 2009·The Journal of Veterinary Medical Science·Thanmaporn PhichitrasilpYasuo Kiso

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