A Study of Human Killer Cell Immunoglobulin-Like Receptor and Multidrug Resistance Gene Polymorphisms in Children With Immune Thrombocytopenia

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Nagham Mohamed Samy El-BeblawyPerehan Mohsen Mahmoud

Abstract

This study was undertaken to detect characterization of the different gene polymorphisms in Human killer cell immunoglobulin-like receptor (KIR2) gene and multi-drug resistance (MDR1) gene, among childhood ITP Egyptian patients. In addition to assess the potential role of these polymorphisms in relation to types of ITP and response to different treatment modalities. A total of 48 pediatric patients with immune thrombocytopenia (ITP; 24 newly diagnosed and 24 chronic) and 35 healthy controls were investigated via polymerase chain reaction-restriction fragment length polymorphism analysis for multidrug resistance (MDR) 1 and killer cell immunoglobulin-like receptor (KIR) 2 genes. The frequency of MDR1 gene in patients and control was not significant (P = .090). The CT genotype was the highest distribution among all ITP cases (62.50%, n = 30) and control (48.60%, n = 17). There was a significant difference in age at diagnosis of MDR1 gene with the CC genotype had the eldest age and lowest initial platelets count (P = .029 and P = .004). The distribution of KIR2 gene among all patients with ITP and controls was significant (P = .026) with (KIRDL2-/KIRDS2-) genotype was the most prevalent among patients. The frequency of MDR1 polymo...Continue Reading

References

Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·F ThiebautM C Willingham
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C Cordon-CardoJ R Bertino
Jan 16, 1998·Immunity·M UhrbergP Parham
Jun 29, 2002·Journal of the American Society of Nephrology : JASN·Michael SiegsmundHiltrud Brauch
Jul 2, 2003·Pharmacogenomics·Toshiyuki SakaedaKatsuhiko Okumura
Aug 2, 2003·Pharmacogenetics·Deanna L KroetzUNKNOWN Pharmacogenetics of Membrane Transporters Investigators
Apr 28, 2004·Autoimmunity Reviews·Yvonne Richaud-PatinLuis Llorente
May 18, 2004·Arthritis and Rheumatism·T MomotT Witte
Jun 26, 2004·Clinical Pharmacokinetics·Ichiro IeiriKenji Otsubo
Jul 29, 2004·The Journal of Pharmacology and Experimental Therapeutics·Hiroshi TakaneIchiro Ieiri
Sep 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·George W NelsonMary Carrington
Apr 22, 2005·Critical Reviews in Oncology/hematology·Bin ZhouZhong Chao Han
Sep 6, 2005·Pharmacogenetics and Genomics·Danxin WangWolfgang Sadée
Aug 26, 2006·European Journal of Clinical Pharmacology·Marek DrozdzikMagdalena Herczynska
Dec 23, 2006·Science·Chava Kimchi-SarfatyMichael M Gottesman
May 25, 2007·Clinical and Experimental Immunology·R J Boyton, D M Altmann
Apr 9, 2008·European Journal of Haematology. Supplementum·Terry Gernsheimer
Feb 3, 2009·Rheumatology·David P LoweUNKNOWN UK Sjögren's Interest Group
Apr 28, 2009·Blood·Douglas B CinesEline T Luning Prak
Mar 24, 2010·Annals of Hematology·Anke K BergmannEllis J Neufeld
Nov 19, 2010·British Journal of Haematology·Lisa J Toltl, Donald M Arnold
Apr 5, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tabrez JafarSuraksha Agrawal
May 10, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hyun Jin ChoiHae Il Cheong
Oct 26, 2011·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Jamie P NourseMaher K Gandhi
May 23, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Yee-Hsuan ChiouShiao-ping Huang
Oct 18, 2012·Journal of Pediatric Hematology/oncology·John A D'OrazioNina Farhoudi
Sep 5, 2011·Turkish Journal of Haematology : Official Journal of Turkish Society of Haematology·Emel OkuluNejat Akar

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Methods Mentioned

BETA
PCR
Genotyping
electrophoresis
Assay

Software Mentioned

SPSS
Statistical Program for IBM
Gel Documentation System

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