PMID: 6972509Jan 1, 1981Paper

A study of immunoregulation of BALB/c mice by Echinococcus granulosus equinus during prolonged infection

Parasite Immunology
D AllanJ B Dixon

Abstract

Two models of intraperitoneal infection with E. granulosus equinus by protoscolices and by cyst passage in BALB/c mice were used to provide mesenteric lymph node cells for adoptive cell transfer into syngeneic recipient normal responder mice. The cell transfer inocula were shown to have depleted Thy-1 cells, but to be highly suppressive to the normal sheep erythrocyte response of the recipients. The nature of the depletion and non-specific suppression, and the infectious nature of the latter, are discussed in relation to other examples of mitogenic stimulation resulting in non-specific T cell suppressor activity. The functions of Ly-2,3+ cells, not only as suppressor, but as alloreactive cytotoxic cells, are discussed as a possible, autoimmune explanation for the longevity of the parasite within the mouse model, in contradistinction to the predictable early rejection of analogous xenografts.

References

Mar 1, 1978·European Journal of Immunology·G Kelsoe, J Cerny
Jan 1, 1979·Annual Review of Medicine·H Cantor
Aug 1, 1972·The Journal of Experimental Medicine·E S Golub
Feb 1, 1980·Annals of Tropical Medicine and Parasitology·R J Connor

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Citations

Oct 1, 1986·International Journal for Parasitology·L M KumaratilakeJ Eckert
Jul 1, 1990·International Journal for Parasitology·M W Lightowlers
Sep 1, 1991·International Journal for Parasitology·R P DempsterD D Heath
Jan 15, 1992·Veterinary Immunology and Immunopathology·N K RakhaP Jenkins
Nov 14, 1997·The Journal of Small Animal Practice
Dec 1, 1996·Immunology and Cell Biology·M RiffkinP Wood
Mar 8, 2011·Trends in Parasitology·Alvaro DíazAna M Ferreira
Oct 2, 2015·Parasite Immunology·A DíazA M Ferreira
Jun 1, 1990·Annals of Tropical Medicine and Parasitology·J L MolinariJ M Cázares
Jun 1, 1984·Annals of Tropical Medicine and Parasitology·D A CoxS Marshall-Clarke

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