A study of indefinite for dysplasia in Barrett's oesophagus: reproducibility of diagnosis, clinical outcomes and predicting progression with AMACR (alpha-methylacyl-CoA-racemase)

Histopathology
Sunil A SonwalkarSimon M Everett

Abstract

To assess interobserver variation in the diagnosis of dysplasia in Barrett's oesophagus, especially indefinite dysplasia (IND) using the revised Vienna classification. A secondary aim was to study clinical outcome of IND cases and to evaluate expression of alpha-methyl-CoA racemase (AMACR) as a marker predictive of progression. Cases of Barrett's oesophagus and dysplasia over a 20 year period were assessed. Three experienced histopathologists reviewed 101 cases on set criteria in a blinded fashion. Slides were immunostained for AMACR and evaluated for the presence, extent and location of AMACR expression. Clinical and progression data were collected. Overall agreement for the diagnosis of dysplasia was fair (k = 0.35) but that for IND was poor (k = 0.18). 6 IND cases progressed after a median follow-up of 31.4 months to a higher grade. The sensitivity of AMACR for the detection of abnormality was 22% for IND and specificity 100%. The positive predictive value of AMACR for progression was 0.44 and the negative predictive value was 0.92. Fair agreement was achieved for the diagnosis of dysplasia but poor agreement for IND. A proportion of IND cases progress. Re-diagnosis or consensus diagnosis did not predict progression. AMACR s...Continue Reading

References

May 1, 1992·Human Pathology·J E McArdleW Weinstein
Jan 11, 2001·The American Journal of Gastroenterology·M SkacelJ R Goldblum
Apr 3, 2002·JAMA : the Journal of the American Medical Association·Mark A RubinArul M Chinnaiyan
Sep 10, 2002·The American Journal of Surgical Pathology·Zhong JiangXiming J Yang
Dec 27, 2005·Annals of Surgical Oncology·Steven R DeMeester
Sep 26, 2006·Human Pathology·Mikhail LisovskyTawfiqul Bhuiya

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Citations

Nov 30, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Zhao-Xiu LiuBo Shen
May 17, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ying-En LeeChien-Feng Li
Sep 1, 2013·Surgical Pathology Clinics·Mikhail Lisovsky, Amitabh Srivastava
Feb 27, 2014·Clinical Endoscopy·Andrea Grin, Catherine J Streutker
Jan 4, 2012·Histopathology·Glen Kristiansen
Oct 15, 2013·Annals of the New York Academy of Sciences·Henry D AppelmanAndrew M Bellizzi
Oct 1, 2014·Annals of the New York Academy of Sciences·Henry D AppelmanVincenzo Villanacci
Aug 5, 2014·Journal of Gastroenterology and Hepatology·Bela HorvathXiuli Liu
Feb 14, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Nikhil A SangleMary P Bronner
Jan 28, 2016·The American Journal of Surgical Pathology·Bita V NainiRobert D Odze
Mar 7, 2015·Best Practice & Research. Clinical Gastroenterology·Sebastian Zeki, Rebecca C Fitzgerald
Oct 30, 2013·Gut·Rebecca C FitzgeraldUNKNOWN British Society of Gastroenterology
Apr 21, 2016·The American Journal of Surgical Pathology·Nicole C Panarelli, Rhonda K Yantiss
Feb 12, 2017·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M MaG W Falk
Sep 8, 2016·World Journal of Gastrointestinal Pharmacology and Therapeutics·Prashanthi N ThotaXiu-Li Liu
Mar 21, 2019·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Yu Sen Alex SohUNKNOWN Asian Barrett's Consortium
Jun 13, 2014·World Journal of Surgery·Giovanni Zaninotto, Cathy Bennett
May 14, 2020·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Andrew J HennBrian J Hanson
May 28, 2019·Nature Reviews. Disease Primers·Yonne PetersPeter D Siersema
Nov 17, 2016·Scandinavian Journal of Gastroenterology·Svein Olav BratlieLars Fändriks
Feb 23, 2020·American Journal of Clinical Pathology·Hira YousafHector Mesa
Jan 1, 2021·Histopathology·M Priyanthi KumarasingheSpiro C Raftopoulos
May 8, 2020·Journal of Clinical Gastroenterology·James E AllenPrateek Sharma
Aug 20, 2019·Gastrointestinal Endoscopy·Rajesh KrishnamoorthiPrasad G Iyer
Feb 7, 2021·Gastrointestinal Endoscopy·Richard PhillipsMassimiliano di Pietro
Jun 11, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Christopher J BowmanWon-Tak Choi

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