A study of induction of nerve regeneration using bioabsorbable tubes

Journal of Reconstructive Microsurgery
S ItohK Schinomiya

Abstract

A silicone tube (S-tube) was packed with CPLA (copolymer of poly-L-lactide) fibers (S-tube+CPLA) or collagen fibers (S-tube+fiber). Two types of tube were prepared from a collagen sheet (Col-tube) and a bioabsorbable atelocollagen membrane for guided tissue regeneration (GTR-tube). They were packed with collagen fibers or films (Col-tube+fiber, GTR-tube+fiber and GTR-tube+film). Bridge grafting (15 mm in length) was performed with these tubes in a rat sciatic nerve model. Specimens were harvested after 8 weeks. Minifascicles were formed in the open space between the CPLA fibers in the S-tube+CPLA group. Regenerated axons were also formed in the degenerated collagen fibers in the S-tube+Col group. Immunocytochemistry evaluation revealed that Schwann cells invaded the space in the absorbing collagen fibers. Histologic analysis of the regenerated axons in the groups with Col-tubes or GTR-tubes revealed that both the Col-tube and the GTR-tube packed with collagen fibers were effective in providing a scaffold for regenerating nerve tissue.

Citations

Dec 31, 2008·Journal of Materials Science. Materials in Medicine·Ming-Chin LuYueh-Sheng Chen
Jan 5, 2011·Journal of Biomaterials Science. Polymer Edition·Chun-Yang WangFeng-Feng Li
Feb 9, 2005·Journal of Biomaterials Science. Polymer Edition·Rebecca Kuntz Willits, Stacy L Skornia
Aug 11, 2007·Journal of Biomaterials Science. Polymer Edition·Ming-Chin LuYueh-Sheng Chen
Dec 31, 2015·Microsurgery·Matthias A ReichenbergerSebastian Fischer
Sep 21, 2010·Acta Biomaterialia·Chun-Yang WangFeng-Feng Li
May 19, 2009·Biomaterials·Isaac P ClementsRavi V Bellamkonda
Feb 4, 2010·Journal of Neuroscience Research·Petrica-Adrian Panaite, Ibtissam Barakat-Walter
Sep 23, 2009·Experimental Neurology·Xu JiangSing Yian Chew
Aug 10, 2005·Journal of Biomedical Materials Research. Part a·Jie CaiGeorge M Smith
Dec 24, 2005·Macromolecular Bioscience·Gianluca Ciardelli, Valeria Chiono

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.