A study of interleukin-8 and defensins in urine and plasma of patients with pyelonephritis and glomerulonephritis

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
I TikhonovA Chyzh

Abstract

Interleukin-8 (IL-8) plays a crucial role in the recruitment and activation of polymorphonucleated leukocytes (PMN) in the site of inflammation. Defensins are specific cationic proteins from azurophil PMN granules which exert antimicrobial, cytotoxic and proinflammatory activities. Urine and plasma levels of IL-8 and defensins were studied using specific enzyme-linked immunosorbent assays. IL-8 was determined in 107 patients, including 45 with chronic glomerulonephritis (GN) and 62 with chronic pyelonephritis (PN). Urine and plasma levels of defensins were studied simultaneously in 29 patients with GN and 29 with PN. None of the patients examined showed any evidence of renal insufficiency. A group of 24 healthy volunteers was used as a control. Urinary IL-8 was significantly increased in all groups of patients comparing with healthy control (< 30 pg/ml). The level of IL-8 in the urine of patients with PN (477 +/- 114 pg/ml, mean +/- SEM) was significantly (P < 0.001) higher than in patients with GN (53 +/- 7 pg/ml). The concentration of defensins in urine of patients with GN was slightly increased in comparison with the normal level (21 +/- 3.5 ng/ml versus 15.7 +/- 2.8 ng/ml). Urinary defensins were significantly elevated in p...Continue Reading

Citations

Feb 24, 2012·PloS One·John David SpencerAndrew L Schwaderer
Jun 5, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·John David SpencerDavid S Hains
May 19, 2009·The Journal of Urology·Ased S M AliRobert S Pickard
Feb 18, 2016·Pediatric Research·Joshua R WatsonAndrew L Schwaderer
Jul 8, 2015·Nature Reviews. Nephrology·Brian BecknellJohn David Spencer
Mar 5, 2016·Journal of the American Society of Nephrology : JASN·Andrew L SchwadererDavid S Hains

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