PMID: 11902174Oct 1, 1979Paper

A study of metabolic balance in crewmembers of Skylab IV

Acta Astronautica
P C RambautG D Whedon

Abstract

A metabolic balance study was conducted on the three crewmembers of the 84-day Skylab IV earth orbital mission. Dietary intake was controlled, monitored, and kept very nearly constant for a period commencing 21 days prior to flight, throughout flight, and for a period of 18 days postflight. Within the first 30 days of flight urine calcium rose to a level approx. 100% above preflight levels and remained elevated for the remainder of the flight. Fecal calcium excretion increased more slowly but continued to accelerate throughout the flight and did not return to baseline levels during the postflight period. Urinary nitrogen increased to 25-30% above preflight levels within one month following launch and thereafter gradually subsided toward control values. The overall losses of calcium averaged approx. 200 mg per day throughout the mission while nitrogen losses averaged 590 mg. Various other indices of musculoskeletal deterioration are discussed and correlated. The parallelism between the effects of weightlessness and bed rest is reviewed. It is noted, that no evidence is yet available as to the identity of the initial biological response to the absence of gravity.

References

Jan 1, 1975·Nutrition and Metabolism·P C RambautP C Johnson
Jan 1, 1974·Nutrition and Metabolism·P C JohnsonC S Leach
May 1, 1974·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·G P Vose
Dec 1, 1971·The Journal of Clinical Investigation·S B HulleyS N Rosen
Sep 1, 1969·The Journal of Clinical Endocrinology and Metabolism·L LutwakH S Lipscomb
Jan 1, 1948·The American Journal of Medicine·J E DEITRICKE SHORR

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Citations

Aug 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A D LeblancJ M Krebs
Nov 1, 1987·Calcified Tissue International·A LeBlancP Johnson
Jan 22, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A LeblancH Ohshima
Sep 1, 1981·Acta Astronautica·L F Dietlein, R S Johnston
Jul 1, 1992·Acta Astronautica·M F Holick
Jul 1, 1992·Acta Astronautica·A LeBlanc, V Schneider
Feb 1, 1995·Acta Astronautica·M HeerD Hoetzel
Jan 1, 1991·Experimental Gerontology·A LeBlanc, V Schneider
Nov 9, 1985·Lancet·P C Rambaut, A W Goode
Sep 7, 2001·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·E Zerath
May 26, 1998·Bone·A LeBlancV Schneider
Jan 1, 1982·Metabolic Bone Disease & Related Research·T J Wronski, E R Morey
Jan 31, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Matthew J AndersonBlaine A Christiansen
Aug 11, 2001·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·P M Loomer
Mar 22, 2018·Nature Reviews. Rheumatology·Laurence Vico, Alan Hargens
Nov 11, 2018·Journal of Cellular Physiology·Yini QiaoJuan Li
Sep 19, 1985·Nature·A W Goode, P C Rambaut
Apr 6, 2000·Journal of Applied Physiology·E R Morey-HoltonS B Doty
Jan 14, 1999·The American Journal of Physiology·W DehorityE Morey-Holton
Dec 22, 2016·The Journal of Physiological Sciences : JPS·Kunihiko TanakaYasuaki Kawai
Jan 22, 1998·The American Journal of Physiology·P J KostenuikD D Bikle
Aug 14, 2001·American Journal of Physiology. Endocrinology and Metabolism·T P Stein, C E Wade
Jan 4, 2020·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Yasir ArfatCharles H Hocart
Jul 9, 1998·Journal of Applied Physiology·T J WronskiB P Halloran
Jun 16, 1999·Journal of Applied Physiology·S M WimalawansaS J Wimalawansa

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